Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1992 Oct;67(10):1267–1271. doi: 10.1136/adc.67.10.1267

Intravenous immunoglobulin in HIV-I infected haemophilic patients.

N Wagner 1, R Bialek 1, H Radinger 1, H H Brackmann 1, M Becker 1
PMCID: PMC1793904  PMID: 1444526

Abstract

In order to evaluate the efficacy of intravenous immunoglobulin (IVIG) in the early stages of HIV infection (patients without AIDS or AIDS related complex) a prospective controlled open trial was conducted in 36 patients (age 6-19 years) with haemophilia. Eighteen patients received 0.3 g/kg IVIG at two week intervals; 18 patients served as controls. Major criteria for the evaluation were progression of HIV disease assessed by the modified Brodt/Helm classification, number of infectious events and HIV associated thrombocytopenia, and the CD4+ T cell count. After 24 months of evaluation seven patients in the IVIG group and five patients in the control group deteriorated according to their staging, with one patient in each group developing AIDS. Thrombocytopenia and infectious events, but no severe bacterial infections, occurred in both groups in similar numbers. The absolute CD4+ T cell count decreased by 284/microliters in the IVIG group and by 143/microliters in the control group respectively (mean values). The statistical analysis of these criteria did not reveal any significant difference. In conclusion, IVIG was not effective in the early stages of HIV infection in patients with haemophilia. IVIG did not slow down the progression of HIV disease and did not prevent the development of an immunodeficiency as assessed by the CD4+ T cell count.

Full text

PDF
1267

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ammann A. J., Ashman R. F., Buckley R. H., Hardie W. R., Krantmann H. J., Nelson J., Ochs H., Stiehm E. R., Tiller T., Wara D. W. Use of intravenous gamma-globulin in antibody immunodeficiency: results of a multicenter controlled trial. Clin Immunol Immunopathol. 1982 Jan;22(1):60–67. doi: 10.1016/0090-1229(82)90022-8. [DOI] [PubMed] [Google Scholar]
  2. Bernstein L. J., Krieger B. Z., Novick B., Sicklick M. J., Rubinstein A. Bacterial infection in the acquired immunodeficiency syndrome of children. Pediatr Infect Dis. 1985 Sep-Oct;4(5):472–475. doi: 10.1097/00006454-198509000-00005. [DOI] [PubMed] [Google Scholar]
  3. Brodt H. R., Helm E. B., Werner A., Joetten A., Bergmann L., Klüver A., Stille W. Spontanverlauf der LAV/HTLV-III-Infektion. Verlaufsbeobachtungen bei Personen aus AIDS-Risikogruppen. Dtsch Med Wochenschr. 1986 Aug 1;111(31-32):1175–1180. doi: 10.1055/s-2008-1068603. [DOI] [PubMed] [Google Scholar]
  4. Eibl M. M., Wedgwood R. J. Intravenous immunoglobulin: a review. Immunodefic Rev. 1989;1 (Suppl):1–42. [PubMed] [Google Scholar]
  5. Giesecke J., Scalia-Tomba G., Berglund O., Berntorp E., Schulman S., Stigendal L. Incidence of symptoms and AIDS in 146 Swedish haemophiliacs and blood transfusion recipients infected with human immunodeficiency virus. BMJ. 1988 Jul 9;297(6641):99–102. doi: 10.1136/bmj.297.6641.99. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goedert J. J., Kessler C. M., Aledort L. M., Biggar R. J., Andes W. A., White G. C., 2nd, Drummond J. E., Vaidya K., Mann D. L., Eyster M. E. A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia. N Engl J Med. 1989 Oct 26;321(17):1141–1148. doi: 10.1056/NEJM198910263211701. [DOI] [PubMed] [Google Scholar]
  7. Hunziker U. A., Nadal D., Jendis J. B., Tomasik Z., Wetzel J. C., Schüpbach J., Seger R. A. Stable human immunodeficiency virus encephalopathy in two infants receiving early intravenous gammaglobulin plus antimicrobial prophylaxis. Eur J Pediatr. 1989 Feb;148(5):417–422. doi: 10.1007/BF00595901. [DOI] [PubMed] [Google Scholar]
  8. Jason J. M., Stehr-Green J., Holman R. C., Evatt B. L. Human immunodeficiency virus infection in hemophilic children. Pediatrics. 1988 Oct;82(4):565–570. [PubMed] [Google Scholar]
  9. Johnson R. E., Lawrence D. N., Evatt B. L., Bregman D. J., Zyla L. D., Curran J. W., Aledort L. M., Eyster M. E., Brownstein A. P., Carman C. J. Acquired immunodeficiency syndrome among patients attending hemophilia treatment centers and mortality experience of hemophiliacs in the United States. Am J Epidemiol. 1985 Jun;121(6):797–810. doi: 10.1093/oxfordjournals.aje.a114051. [DOI] [PubMed] [Google Scholar]
  10. Kamani N., Lightman H., Leiderman I., Krilov L. R. Pediatric acquired immunodeficiency syndrome-related complex: clinical and immunologic features. Pediatr Infect Dis J. 1988 Jun;7(6):383–388. doi: 10.1097/00006454-198806000-00003. [DOI] [PubMed] [Google Scholar]
  11. Krasinski K., Borkowsky W., Bonk S., Lawrence R., Chandwani S. Bacterial infections in human immunodeficiency virus-infected children. Pediatr Infect Dis J. 1988 May;7(5):323–328. doi: 10.1097/00006454-198805000-00006. [DOI] [PubMed] [Google Scholar]
  12. Milner A. D., Hoskyns E. W. High frequency positive pressure ventilation in neonates. Arch Dis Child. 1989 Jan;64(1 Spec No):1–3. doi: 10.1136/adc.64.1_spec_no.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Monro J., Brostoff J., Carini C., Zilkha K. Food allergy in migraine. Study of dietary exclusion and RAST. Lancet. 1980 Jul 5;2(8184):1–4. doi: 10.1016/s0140-6736(80)92887-1. [DOI] [PubMed] [Google Scholar]
  14. Schaad U. B., Gianella-Borradori A., Perret B., Imbach P., Morell A. Intravenous immune globulin in symptomatic paediatric human immunodeficiency virus infection. Eur J Pediatr. 1988 Apr;147(3):300–303. doi: 10.1007/BF00442700. [DOI] [PubMed] [Google Scholar]
  15. Teitel J. M., Freedman J. J., Garvey M. B., Kardish M. Two-year evaluation of clinical and laboratory variables of immune function in 117 hemophiliacs seropositive or seronegative for HIV-1. Am J Hematol. 1989 Dec;32(4):262–272. doi: 10.1002/ajh.2830320406. [DOI] [PubMed] [Google Scholar]
  16. Wagner N., Bialek R., Radinger H., Becker M., Schneweis K. E., Brackmann H. H., Niese D. HIV-1 infection in a cohort of haemophilic patients. Arch Dis Child. 1990 Dec;65(12):1301–1304. doi: 10.1136/adc.65.12.1301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Weeks J. C., Tierney M. R., Weinstein M. C. Cost effectiveness of prophylactic intravenous immune globulin in chronic lymphocytic leukemia. N Engl J Med. 1991 Jul 11;325(2):81–86. doi: 10.1056/NEJM199107113250202. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES