Abstract
Two cases of vena caval thrombosis in infants were successfully treated with low dose (0.01-0.05 mg/kg/hour) local infusions of tissue plasminogen activator after conventional anticoagulant treatment had been unsuccessful. This approach is useful for clots associated with indwelling intravascular catheters, and a low dose infusion of tissue plasminogen activator as a regional application is recommended to achieve clot lysis with minimal systemic effects.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anderson B. J., Keeley S. R., Johnson N. D. Caval thrombolysis in neonates using low doses of recombinant human tissue-type plasminogen activator. Anaesth Intensive Care. 1991 Feb;19(1):22–27. doi: 10.1177/0310057X9101900104. [DOI] [PubMed] [Google Scholar]
- Levy M., Benson L. N., Burrows P. E., Bentur Y., Strong D. K., Smith J., Johnson D., Jacobson S., Koren G. Tissue plasminogen activator for the treatment of thromboembolism in infants and children. J Pediatr. 1991 Mar;118(3):467–472. doi: 10.1016/s0022-3476(05)82170-5. [DOI] [PubMed] [Google Scholar]
- Marder V. J., Sherry S. Thrombolytic therapy: current status (2). N Engl J Med. 1988 Jun 16;318(24):1585–1595. doi: 10.1056/NEJM198806163182406. [DOI] [PubMed] [Google Scholar]
- Mueller H. S., Rao A. K., Forman S. A. Thrombolysis in myocardial infarction (TIMI): comparative studies of coronary reperfusion and systemic fibrinogenolysis with two forms of recombinant tissue-type plasminogen activator. J Am Coll Cardiol. 1987 Sep;10(3):479–490. doi: 10.1016/s0735-1097(87)80188-2. [DOI] [PubMed] [Google Scholar]
- Naylor C. D., Armstrong P. W. Guidelines for the use of intravenous thrombolytic agents in acute myocardial infarction. Ontario Medical Association Consensus Group on Thrombolytic Therapy. CMAJ. 1989 Jun 1;140(11):1289–1299. [PMC free article] [PubMed] [Google Scholar]
- Wilcox R. G., von der Lippe G., Olsson C. G., Jensen G., Skene A. M., Hampton J. R. Trial of tissue plasminogen activator for mortality reduction in acute myocardial infarction. Anglo-Scandinavian Study of Early Thrombolysis (ASSET). Lancet. 1988 Sep 3;2(8610):525–530. doi: 10.1016/s0140-6736(88)92656-6. [DOI] [PubMed] [Google Scholar]