Abstract
An encephalitic illness with a fatal outcome occurred in a 9 month old girl with virologically confirmed exanthem subitum. Human herpes-virus-6 (HHV-6) DNA was found in the cerebrospinal fluid at the acute stage of the disease by the polymerase chain reaction, but the virus antigen was not detected in her brain tissue. This suggests that HHV-6-induced encephalitis/encephalopathy may be due to a non-infectious process.
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Selected References
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- Asano Y., Yoshikawa T., Suga S., Yazaki T., Hata T., Nagai T., Kajita Y., Ozaki T., Yoshida S. Viremia and neutralizing antibody response in infants with exanthem subitum. J Pediatr. 1989 Apr;114(4 Pt 1):535–539. doi: 10.1016/s0022-3476(89)80689-4. [DOI] [PubMed] [Google Scholar]
- Ishiguro N., Yamada S., Takahashi T., Takahashi Y., Togashi T., Okuno T., Yamanishi K. Meningo-encephalitis associated with HHV-6 related exanthem subitum. Acta Paediatr Scand. 1990 Oct;79(10):987–989. doi: 10.1111/j.1651-2227.1990.tb11369.x. [DOI] [PubMed] [Google Scholar]
- Kondo K., Hayakawa Y., Mori H., Sato S., Kondo T., Takahashi K., Minamishima Y., Takahashi M., Yamanishi K. Detection by polymerase chain reaction amplification of human herpesvirus 6 DNA in peripheral blood of patients with exanthem subitum. J Clin Microbiol. 1990 May;28(5):970–974. doi: 10.1128/jcm.28.5.970-974.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kurata T., Hondo R., Sato S., Oda A., Aoyama Y., McCormick J. B. Detection of viral antigens in formalin-fixed specimens by enzyme treatment. Ann N Y Acad Sci. 1983;420:192–207. doi: 10.1111/j.1749-6632.1983.tb22204.x. [DOI] [PubMed] [Google Scholar]
- Yamanishi K., Kondo K., Mukai T., Kondo T., Nagafuji H., Kato T., Okuno T., Kurata T. Human herpesvirus 6 (HHV-6) infection in the central nervous system. Acta Paediatr Jpn. 1992 Jun;34(3):337–343. doi: 10.1111/j.1442-200x.1992.tb00969.x. [DOI] [PubMed] [Google Scholar]
- Yoshikawa T., Nakashima T., Suga S., Asano Y., Yazaki T., Kimura H., Morishima T., Kondo K., Yamanishi K. Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. Pediatrics. 1992 May;89(5 Pt 1):888–890. [PubMed] [Google Scholar]