Abstract
Of 40 patients with obstructive pulmonary hypertension studied in Basle, Switzerland, during the period 1966-68, 32 had been taking an anorectic drug, aminorex fumarate. Rapidly progressing exertional dyspnoea, central chest pain, and syncope on effort were characteristic features. The absence of the usual causes of pulmonary vascular disease seems to suggest the possibility of drug-induced pulmonary hypertension. Further studies are necessary, however, to clarify the role of aminorex fumarate in this condition.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BROWN J. W., HEATH D., WHITAKER W. Idiopathic pulmonary hypertension. Br Heart J. 1957 Jan;19(1):83–92. doi: 10.1136/hrt.19.1.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Burkart F., Follath F., Jenzer H. R. Der Verlauf der obstruktiven pulmonalen arteriellen Hypertension. Schweiz Med Wochenschr. 1970 Jan 24;100(4):146–148. [PubMed] [Google Scholar]
- DRESDALE D. T., SCHULTZ M., MICHTOM R. J. Primary pulmonary hypertension. I. Clinical and hemodynamic study. Am J Med. 1951 Dec;11(6):686–705. doi: 10.1016/0002-9343(51)90020-4. [DOI] [PubMed] [Google Scholar]
- GOODWIN J. F., HARRISON C. V., WILCKEN D. E. Obliterative pulmonary hypertension and thrombo-embolism. Br Med J. 1963 Mar 16;1(5332):701–contd. doi: 10.1136/bmj.1.5332.701. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gurtner H. P., Gertsch M., Salzmann C., Scherrer M., Stucki P., Wyss F. Häufen sich die primär vasculären Formen des chronischen Cor pulmonale? Schweiz Med Wochenschr. 1968 Oct 26;98(43):1695–1707. [PubMed] [Google Scholar]
- Harmjanz, Gahl, Stender, Fabel, Deicher Zur medikamentös induzierten pulmonalen Hypertonie. Dtsch Med Wochenschr. 1968 Nov 29;93(48):2351–2351. [PubMed] [Google Scholar]
- Jornod J., Widgren S., Fischer G. Etude anatomo-clinique d'un cas d'hypertension artérielle pulmonaire chez une jeune femme. Schweiz Med Wochenschr. 1970 Jan 24;100(4):151–158. [PubMed] [Google Scholar]
- Kay J. M., Harris P., Heath D. Pulmonary hypertension produced in rats by ingestion of Crotalaria spectabilis seeds. Thorax. 1967 Mar;22(2):176–179. doi: 10.1136/thx.22.2.176. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lang E., Haupt E. J., Köhler J. A., Schmidt J. Cor pulmonale durch Appetitzügler? Munch Med Wochenschr. 1969 Feb 21;111(8):405–412. [PubMed] [Google Scholar]
- OWEN W. R., THOMAS W. A., CASTLEMAN B., BLAND E. F. Unrecognized emboli to the lungs with subsequent cor pulmonale. N Engl J Med. 1953 Dec 3;249(23):919–926. doi: 10.1056/NEJM195312032492302. [DOI] [PubMed] [Google Scholar]
- Oakley C., Somerville J. Oral contraceptives and progressive pulmonary vascular disease. Lancet. 1968 Apr 27;1(7548):890–893. doi: 10.1016/s0140-6736(68)90240-7. [DOI] [PubMed] [Google Scholar]
- Rivier J. L. Hypertension artérielle pulmonaire primitive. Résultats statistique préliminaires sous l'égide de la Société suisse de Cardiologie et avec l'aide de la Fondation suisse de Cardiologie. Schweiz Med Wochenschr. 1970 Jan 24;100(4):143–145. [PubMed] [Google Scholar]
- SCHWEIZER W., HERZOG H., JENNY M., von CAPELLER D. [Primary pulmonary arterial hypertension]. Cardiologia. 1959;35:365–376. [PubMed] [Google Scholar]
- SMITH G. T., DAMMIN G. J., DEXTER L. POSTMORTEM ARTERIOGRAPHIC STUDIES OF THE HUMAN LUNG IN PULMONARY EMBOLIZATION. JAMA. 1964 Apr 13;188:143–151. doi: 10.1001/jama.1964.03060280045011. [DOI] [PubMed] [Google Scholar]
- Schweizer W. Obstruktive pulmonale arterielle Hypertension und Menocil. Praxis. 1969 Jun 3;58(22):701–702. [PubMed] [Google Scholar]
- Schwingshackl H., Amor H., Dienstl F. "Primäre" pulmonale Hypertonie bei sieben jüngeren Frauen. Möglichkeit eines Zusammenhanges mit der Einnahme von Aminoresfumarat (Menocil) Dtsch Med Wochenschr. 1969 Mar 28;94(13):639–645. doi: 10.1055/s-0028-1109004. [DOI] [PubMed] [Google Scholar]