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. 1971 Feb 20;1(5746):426–429. doi: 10.1136/bmj.1.5746.426

Clinical Trial of Malaria Prophylaxis in Tropical Splenomegaly Syndrome

Pieter C Stuiver, John L Ziegler, John B Wood, Richard H Morrow, M S R Hutt
PMCID: PMC1795094  PMID: 4925514

Abstract

A controlled, randomized, double-blind trial of malaria prophylaxis in tropical splenomegaly syndrome showed a significant reduction in spleen size and an improvement of anaemia and symptoms in patients treated with antimalarials compared with control subjects receiving placebo. This study confirms the observations from West Africa and provides further indirect evidence for a malarial aetiology of tropical splenomegaly syndrome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRUCE-CHWATT L. J. Biometric study of spleen- and liver-weights in Africans and Europeans, with special reference to endemic malaria. Bull World Health Organ. 1956;15(3-5):513–548. [PMC free article] [PubMed] [Google Scholar]
  2. GEBBIE D. A., HAMILTON P. J., HUTT M. S., MARSDEN P. D., VOLLER A., WILKS N. E. MALARIAL ANTIBODIES IN IDIOPATHIC SPLENOMEGALY IN UGANDA. Lancet. 1964 Aug 22;2(7356):392–393. doi: 10.1016/s0140-6736(64)90396-4. [DOI] [PubMed] [Google Scholar]
  3. HAMILTON P. J., HUTT M. S., WILKS N. E., OLWENY C., NDAWULA R. L., MWANJE L. IDIOPATHIC SPLENOMEGALY IN UGANDA. 1. PATHOLOGICAL ASPECTS. East Afr Med J. 1965 May;42:191–195. [PubMed] [Google Scholar]
  4. Hamilton P. J., Gebbie D. A., Hutt M. S., Lothe F., Wilks N. E. Anaemia in pregnancy associated with "big spleen disease". Br Med J. 1966 Sep 3;2(5513):548–551. doi: 10.1136/bmj.2.5513.548. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lowenthal M. N., Hutt M. S. Serial liver biopsies in big slpeen disease. East Afr Med J. 1968 Mar;45(3):100–109. [PubMed] [Google Scholar]
  6. Marsden P. D., Connor D. H., Voller A., Kelly A., Schofield F. D., Hutt M. S. Splenomegaly in New Guinea. Bull World Health Organ. 1967;36(6):901–911. [PMC free article] [PubMed] [Google Scholar]
  7. Marsden P. D., Hamilton P. J. Splenomegaly in the tropics. Br Med J. 1969 Jan 11;1(5636):99–102. doi: 10.1136/bmj.1.5636.99. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Paliwoda T., Hutt M. S. Splenectomy in cases of gross splenomegaly. An account of 70 cases from Lira Hospital, Uganda. East Afr Med J. 1968 Jan;45(1):1–8. [PubMed] [Google Scholar]
  9. Pitney W. R. The tropical splenomegaly syndrome. Trans R Soc Trop Med Hyg. 1968;62(5):717–728. doi: 10.1016/0035-9203(68)90124-7. [DOI] [PubMed] [Google Scholar]
  10. Sagoe A. S. Tropical splenomegaly syndrome: long-term proguanil therapy correlated with spleen size, serum IgM, and lymphocyte transformation. Br Med J. 1970 Aug 15;3(5719):378–382. doi: 10.1136/bmj.3.5719.378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Watson-Williams E. J., Allan N. C. Idiopathic tropical splenomegaly syndrome in Ibadan. Br Med J. 1968 Dec 28;4(5634):793–796. doi: 10.1136/bmj.4.5634.793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wells J. V. Serum immunoglobulin levels in tropical splenomegaly syndrome in New Guinea. Clin Exp Immunol. 1968 Nov;3(9):943–951. [PMC free article] [PubMed] [Google Scholar]

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