Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1971 Mar 13;1(5749):577–579. doi: 10.1136/bmj.1.5749.577

5-Fluorocytosine and Urinary Candidiasis

R R Davies, D S Reeves
PMCID: PMC1795260  PMID: 5548298

Abstract

Two patients with urinary candidiasis were treated with 5-fluorocytosine. Serum levels of the drug and a study of its excretion in urine are recorded together with a brief account of its activity in body fluids. Evidence of toxicity was not observed with dosages of from 2 to 5 g a day.

Full text

PDF
577

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blum J. A. Acute monilial pyohydronephrosis: report of a case successfully treated with amphotericin B continuous renal pelvis irrigation. J Urol. 1966 Nov;96(5):614–618. doi: 10.1016/S0022-5347(17)63317-2. [DOI] [PubMed] [Google Scholar]
  2. Chilgren R. A., Hong R., Quie P. G. Human serum interactions with Candida albicans. J Immunol. 1968 Jul;101(1):128–132. [PubMed] [Google Scholar]
  3. DAVIS J. B., WHITAKER J. D., DING L. K., KIEFER J. H. Disseminated, fatal postpartum candidiasis with renal suppuration: case report. J Urol. 1956 Jun;75(6):930–936. doi: 10.1016/S0022-5347(17)66906-4. [DOI] [PubMed] [Google Scholar]
  4. GOLDMAN H. J., LITTMAN M. L., OPPENHEIMER G. D., GLICKMAN S. I. Monilial cystitis-effective treatment with instilations of amphotericin B. JAMA. 1960 Sep 24;174:359–362. doi: 10.1001/jama.1960.03030040013004. [DOI] [PubMed] [Google Scholar]
  5. GUZE L. B., HALEY L. D. Fungus infections of the urinary tract. Yale J Biol Med. 1958 Feb;30(4):292–305. [PMC free article] [PubMed] [Google Scholar]
  6. Hendry A. T., Bakerspigel A. Factors affecting serum inhibited growth of Candida albicans and Cryptococcus neoformans. Sabouraudia. 1969 Oct;7(3):219–229. [PubMed] [Google Scholar]
  7. Koechlin B. A., Rubio F., Palmer S., Gabriel T., Duschinsky R. The metabolism of 5-fluorocytosine-2-14-C and of cytosine-14-C in the rat and the disposition of 5-fluorocytosine-2-14-C in man. Biochem Pharmacol. 1966 Apr;15(4):435–446. doi: 10.1016/0006-2952(66)90254-1. [DOI] [PubMed] [Google Scholar]
  8. LOURIA D. B. Some aspects of the absorption, distribution, and excretion of amphotericin B in man. Antibiotic Med Clin Ther (New York) 1958 May;5(5):295–301. [PubMed] [Google Scholar]
  9. Record C. O., Skinner J. M., Sleight P., Speller D. C. Candida endocarditis treated with 5-fluorocytosine. Br Med J. 1971 Jan 30;1(5743):262–264. doi: 10.1136/bmj.1.5743.262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. SENECA H., PEER P. CLINICAL LABORATORY DIAGNOSIS OF URINARY TRACT INFECTIONS. J Urol. 1965 Jul;94:78–81. doi: 10.1016/S0022-5347(17)63574-2. [DOI] [PubMed] [Google Scholar]
  11. Shadomy S. Further in vitro studies with 5-fluorocytosine. Infect Immun. 1970 Oct;2(4):484–488. doi: 10.1128/iai.2.4.484-488.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Shadomy S. In vitro studies with 5-fluorocytosine. Appl Microbiol. 1969 Jun;17(6):871–877. doi: 10.1128/am.17.6.871-877.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Webb A. J., Speller D. C., Buckler K. G. Torulopsis glabrata septicaemia treated with 5-fluorocytosine. Lancet. 1970 Apr 18;1(7651):839–840. doi: 10.1016/s0140-6736(70)92438-4. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES