Abstract
Nine patients with tabes dorsalis and one patient with diabetic autonomic neuropathy were subjected to hypoxia to test the integrity of their carotid chemoreceptors. Ventilation and pulse rate changes were monitored and compared with those of a group of normal subjects of comparable age and sex. Four patients had a completely negative response to hypoxia, and the changes in ventilation in the group of patients as a whole were significantly less than in the control subjects. The results indicate that some patients with autonomic denervation are unable to adjust their respiratory system in response to hypoxia.
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Selected References
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- Holton P., Wood J. B. The effects of bilateral removal of the carotid bodies and denervation of the carotid sinuses in two human subjects. J Physiol. 1965 Nov;181(2):365–378. doi: 10.1113/jphysiol.1965.sp007767. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHARPEY-SCHAFER E. P. Circulatory reflexes in chronic disease of the afferent nervous system. J Physiol. 1956 Oct 29;134(1):1–10. doi: 10.1113/jphysiol.1956.sp005621. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SHARPEY-SCHAFER E. P., TAYLOR P. J. Absent circulatory reflexes in diabetic neuritis. Lancet. 1960 Mar 12;1(7124):559–562. doi: 10.1016/s0140-6736(60)92773-2. [DOI] [PubMed] [Google Scholar]