Abstract
The effect of two oral selective β2-stimulant drugs, salbutamol and terbutaline, on spirometry, arterial blood-gas tensions, pulse, and blood pressure was compared with placebo in a double-blind controlled trial in 12 asthmatic patients. Both drugs increased to forced vital capacity and the forced expiratory volume in 1 second equally for up to five hours, the maximal effect occurring at two to four hours. There was no significant change in arterial blood-gas tensions but both drugs increased pulse rate slightly. Tremor was the most common side effect. Terbutaline seems to be an effective alternative to salbutamol.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AVIADO D. M., Jr, SCHMIDT C. F. Effects of sympathomimetic drugs on pulmonary circulation: with special reference to a new pulmonary vasodilator. J Pharmacol Exp Ther. 1957 Aug;120(4):512–527. [PubMed] [Google Scholar]
- Brittain R. T., Farmer J. B., Jack D., Martin L. E., Simpson W. T. Alpha-[(t-Butylamino)methyl]-4-hydroxy-m-xylene-alpha 1,alpha 3-diol (AH.3365): a selective beta-adrenergic stimulant. Nature. 1968 Aug 24;219(5156):862–863. doi: 10.1038/219862a0. [DOI] [PubMed] [Google Scholar]
- Inman W. H., Adelstein A. M. Rise and fall of asthma mortality in England and Wales in relation to use of pressurised aerosols. Lancet. 1969 Aug 9;2(7615):279–285. doi: 10.1016/s0140-6736(69)90051-8. [DOI] [PubMed] [Google Scholar]
- Kelman G. R., Palmer K. N., Cross M. R. Cardiovascular effects of AH.3365 (salbutamol). Nature. 1969 Mar 29;221(5187):1251–1251. doi: 10.1038/2211251a0. [DOI] [PubMed] [Google Scholar]
- Palmer K. N., Diament M. L. Dynamic and static lung volumes and blood-gas tensions in bronchial asthma. Lancet. 1969 Mar 22;1(7595):591–593. doi: 10.1016/s0140-6736(69)91531-1. [DOI] [PubMed] [Google Scholar]
- Palmer K. N., Legge J. S., Hamilton W. F., Diament M. L. Comparison of effect of salbutamol and isoprenaline on spirometry and blood-gas tensions in bronchial asthma. Br Med J. 1970 Apr 4;2(5700):23–24. doi: 10.1136/bmj.2.5700.23. [DOI] [PMC free article] [PubMed] [Google Scholar]