Skip to main content
British Medical Journal logoLink to British Medical Journal
. 1971 Jan 9;1(5740):78–82. doi: 10.1136/bmj.1.5740.78

Lipoprotein Electrophoretic Patterns, Serum Lipids, and Coronary Heart Disease

J R Masarei, Margaret Summers, D H Curnow, K J Cullen, M G McCall, N S Stenhouse, T A Welborn
PMCID: PMC1795688  PMID: 5539180

Abstract

Lipoprotein electrophoresis was performed on serum from subjects with and without coronary heart disease, and the patterns compared with the serum concentrations of triglyceride and cholesterol. The beta- and pre-beta-lipoproteins, expressed as a percentage of the total lipoprotein, correlate strongly with the cholesterol and triglyceride concentrations, respectively. The beta- and pre-beta-lipoprotein concentrations are even more strongly correlated with these lipid measurements. The lipoprotein pattern does not have greater discriminant value for coronary heart disease than does the triglyceride or cholesterol concentration. There would seem to be little justification for the use of lipoprotein electrophoresis in screening the general population for coronary heart disease.

Full text

PDF
78

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allard C., Goulet C. Usefulness of a simple serum beta-lipoprotein assay: an epidemiological study of an active Montreal population. Can Med Assoc J. 1967 Nov 25;97(22):1321–1328. [PMC free article] [PubMed] [Google Scholar]
  2. BLACKBURN H., KEYS A., SIMONSON E., RAUTAHARJU P., PUNSAR S. The electrocardiogram in population studies. A classification system. Circulation. 1960 Jun;21:1160–1175. doi: 10.1161/01.cir.21.6.1160. [DOI] [PubMed] [Google Scholar]
  3. Chin H. P., Blankenhorn D. H. Separation and quantitative analysis of serum lipoproteins by means of electrophoresis on cellulose acetate. Clin Chim Acta. 1968 May;20(2):305–314. doi: 10.1016/0009-8981(68)90165-4. [DOI] [PubMed] [Google Scholar]
  4. Ewing A. M., Freeman N. K., Lindgren F. T. The analysis of human serum lipoprotein distributions. Adv Lipid Res. 1965;3:25–61. [PubMed] [Google Scholar]
  5. Fredrickson D. S., Levy R. I., Lees R. S. Fat transport in lipoproteins--an integrated approach to mechanisms and disorders. N Engl J Med. 1967 Jan 19;276(3):148–contd. doi: 10.1056/NEJM196701192760305. [DOI] [PubMed] [Google Scholar]
  6. LEES R. S., HATCH F. T. Sharper separation of lipoprotein species by paper electrophoresis in albumin-containing buffer. J Lab Clin Med. 1963 Mar;61:518–528. [PubMed] [Google Scholar]
  7. Mitchell F. L., Pearson J., Strauss W. T. The relationship between serum total cholesterol and beta-lipoprotein. Clin Chim Acta. 1966 Jul;14(1):1–5. doi: 10.1016/0009-8981(66)90055-6. [DOI] [PubMed] [Google Scholar]
  8. Noble R. P. Electrophoretic separation of plasma lipoproteins in agarose gel. J Lipid Res. 1968 Nov;9(6):693–700. [PubMed] [Google Scholar]
  9. Ostrander L. D., Jr, Neff B. J., Block W. D., Francis T., Jr, Epstein F. H. Hyperglycemia and hypertriglyceridemia among persons with coronary heart disease. Ann Intern Med. 1967 Jul;67(1):34–41. doi: 10.7326/0003-4819-67-1-34. [DOI] [PubMed] [Google Scholar]
  10. WALTON K. W., SCOTT P. J. ESTIMATION OF THE LOW-DENSITY (BETA) LIPOPROTEINS OF SERUM IN HEALTH AND DISEASE USING LARGE MOLECULAR WEIGHT DEXTRAN SULPHATE. J Clin Pathol. 1964 Nov;17:627–643. doi: 10.1136/jcp.17.6.627. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES