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. 1971 May 15;2(5758):367–370. doi: 10.1136/bmj.2.5758.367

Oestrogen as a Reticuloendothelial Stimulant in Patients with Cancer

C J Magarey, M Baum
PMCID: PMC1795795  PMID: 5575972

Abstract

Stimulation of reticuloendothelial activity may benefit patients with cancer. Oestrogenic compounds are known to stimulate reticuloendothelial phagocytic activity in animals and a similar effect is demonstrated in patients.

The depression of reticuloendothelial phagocytic activity which follows radiotheraphy in the treatment of cancer can be prevented by the simultaneous administration of stilboestrol. Possibly this could be associated with a more favourable response to therapy, and a controlled trial is needed to establish this.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashley D. J. A male-female differential in tumour incidence. Br J Cancer. 1969 Mar;23(1):21–25. doi: 10.1038/bjc.1969.3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BIOZZI G., HALPERN B. N., BILBEY D., STIFFEL C., BENACERRAF B., MOUTON D. Oestrogènes et fonction phagocytaire du système réticulo-endothélial. C R Seances Soc Biol Fil. 1957;151(7):1326–1331. [PubMed] [Google Scholar]
  3. BRADNER W. T., CLARKE D. A. Stimulation of host defense against experimental cancer. II. Temporal and reversal studies of the zymosan effect. Cancer Res. 1959 Jul;19(6 Pt 1):673–678. [PubMed] [Google Scholar]
  4. Batchelor J. R., Chapman B. A. The influence of sex upon the antibody response to an incompatible tumour. Immunology. 1965 Dec;9(6):553–564. [PMC free article] [PubMed] [Google Scholar]
  5. Bates R. R. Sex hormones and skin tumorigenesis. I. Effect of the estrous cycle and castration on tumorigenesis by 7,12-dimethylbenz[a]-anthracene. J Natl Cancer Inst. 1968 Aug;41(2):559–563. [PubMed] [Google Scholar]
  6. Dao T. L., Yogo H. Enhancement of pulmonary metastases by x-irradiation in rats bearing mammary cancer. Cancer. 1967 Nov;20(11):2020–2025. doi: 10.1002/1097-0142(196711)20:11<2020::aid-cncr2820201131>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  7. Fairley G. H. Immunity to malignant disease in man. Br Med J. 1969 May 24;2(5655):467–473. doi: 10.1136/bmj.2.5655.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Graff R. J., Lappé M. A., Snell G. D. The influence of the gonads and adrenal glands on the immune response to skin grafts. Transplantation. 1969 Feb;7(2):105–111. doi: 10.1097/00007890-196902000-00003. [DOI] [PubMed] [Google Scholar]
  9. HALPERN B. N., STIFFEL C., BIOZZI G., MOUTON D. [Influence of sex hormones on the stimulation of the phagocytic function of the reticuloendothelial system induced by inoculation of the Calmette-Guerin bacillus (BCG) in the mouse]. C R Seances Soc Biol Fil. 1960;154:1994–2001. [PubMed] [Google Scholar]
  10. Halpern B. N., Biozzi G., Stiffel C., Mouton D. Inhibition of tumour growth by administration of killed corynebacterium parvum. Nature. 1966 Nov 19;212(5064):853–854. doi: 10.1038/212853a0. [DOI] [PubMed] [Google Scholar]
  11. KONDO T., MOORE G. E. Production of metastases by treatment with carcinostatic agents. I. Effects of carcinostatic agents on the host. Cancer Res. 1961 Nov;21:1396–1399. [PubMed] [Google Scholar]
  12. MARTIN D. S. Cancer treatment: immunologic and chemotherapeutic interrelationships. JAMA. 1961 Nov 18;178:723–726. doi: 10.1001/jama.1961.73040460001007. [DOI] [PubMed] [Google Scholar]
  13. MARTIN D. S., HAYWORTH P., FUGMANN R. A., ENGLISH R., MCNEILL H. W. COMBINATION THERAPY WITH CYCLOPHOSPHAMIDE AND ZYMOSAN ON A SPONTANEOUS MAMMARY CANCER IN MICE. Cancer Res. 1964 May;24:652–654. [PubMed] [Google Scholar]
  14. MIRAND E. A., LASSER E. C. Hormonal modification of tissue reactions to ionizing radiation. Exp Med Surg. 1955;13(3):234–242. [PubMed] [Google Scholar]
  15. Magarey C. J., Baum M. Reticulo-endothelial activity in humans with cancer. Br J Surg. 1970 Oct;57(10):748–752. doi: 10.1002/bjs.1800571013. [DOI] [PubMed] [Google Scholar]
  16. NICOL T., BILBEY D. L., CHARLES L. M., CORDINGLEY J. L., VERNON-ROBERTS B. OESTROGEN: THE NATURAL STIMULANT OF BODY DEFENCE. J Endocrinol. 1964 Oct;30:277–291. doi: 10.1677/joe.0.0300277. [DOI] [PubMed] [Google Scholar]
  17. NICOL T., HELMY I. D., ABOU-ZIKRY A. A histological explanation for the beneficial action of endocrine therapy in carcinoma of the prostate. Br J Surg. 1952 Sep;40(160):166–172. doi: 10.1002/bjs.18004016017. [DOI] [PubMed] [Google Scholar]
  18. Nicol T., Vernon-Roberts B., Quantock D. C. The influence of various hormones on the reticulo-endothelial system: endocrine control of body defense. J Endocrinol. 1965 Nov;33(3):365–383. doi: 10.1677/joe.0.0330365. [DOI] [PubMed] [Google Scholar]
  19. OLD L. J., BENACERRAF B., CLARKE D. A., CARSWELL E. A., STOCKERT E. The role of the reticuloendothelial system in the host reaction to neoplasia. Cancer Res. 1961 Oct;21:1281–1300. [PubMed] [Google Scholar]
  20. OLD L. J., BOYSE E. A. IMMUNOLOGY OF EXPERIMENTAL TUMORS. Annu Rev Med. 1964;15:167–186. doi: 10.1146/annurev.me.15.020164.001123. [DOI] [PubMed] [Google Scholar]
  21. Reiner J., Southam C. M. Effect of immunosuppression on first-generation isotransplantation of chemically induced tumours in mice. Nature. 1966 Apr 23;210(5034):429–430. doi: 10.1038/210429a0. [DOI] [PubMed] [Google Scholar]
  22. Rosenau W., Moon H. D. Suppression of the immune response to antigenic tumors in isogenic mice by whole-body irradiation. Cancer Res. 1967 Nov;27(11):1973–1981. [PubMed] [Google Scholar]
  23. SOKOLOFF B., TODA Y., FUJISAWA M., ENOMOTO K., SAELHOF C. C., BIRD L., MILLER C. Experimental studies on Mitomycin C. 4. Zymosan and the R. E. S. Growth. 1961 Sep;25:249–263. [PubMed] [Google Scholar]
  24. Thunold S. Sex differences in tumour growth and lymphoid reactions in mice with Ehrlich's ascites carcinoma. Acta Pathol Microbiol Scand. 1967;69(4):521–533. doi: 10.1111/j.1699-0463.1967.tb03761.x. [DOI] [PubMed] [Google Scholar]
  25. WEISS D. W., BONHAG R. S., DEOME K. B. Protective activity of fractions of tubercle bacilli against isologous tumours in mice. Nature. 1961 Jun 3;190:889–891. doi: 10.1038/190889a0. [DOI] [PubMed] [Google Scholar]
  26. Yamaguchi I., Takahashi T., Narisawa T., Hiroki T. An experimental study on the effect of reticuloendothelial activity on metastasis and recurrence of tumor. Tohoku J Exp Med. 1965 Dec 25;87(3):338–350. doi: 10.1620/tjem.87.338. [DOI] [PubMed] [Google Scholar]

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