Abstract
Silicone 300 has been evaluated as an artificial lubricant in osteoarthrotic joints by means of a pilot study in five inpatients and a control trial of 25 outpatients with 40 osteoarthrotic knees. Sequential analysis showed a significant benefit from saline compared with silicone at one week follow-up and no significant difference at one month.
Measurement of stiffness with a knee arthrograph showed no difference in reduction of stiffness between the two substances. In a study of 18 rabbits there was no evidence that silicone was retained in the joint cavity for longer than 48 hours. There was a failure of clearance of iodinated serum albumin for as long as three to four days after the injection of silicone, suggesting some obstruction to lymphatic outflow. Experimentally produced cartilaginous defects did not heal quicker with the injection of silicone into the joint.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CHANDLER G. N., WRIGHT V., HARTFALL S. J. Intra-articular therapy in rheumatoid arthritis: comparison of hydrocortisone tertiary butyl acetate and hydrocortisone acetate. Lancet. 1958 Sep 27;2(7048):659–661. doi: 10.1016/s0140-6736(58)92261-x. [DOI] [PubMed] [Google Scholar]
- CHARNLEY J. How our joints are lubricated. Triangle. 1960 Apr;4:175–179. [PubMed] [Google Scholar]
- Corbett M., Seifert M. H., Hacking C., Webb S. Comparison between local injections of silicone oil and hydrocortisone acetate in chronic arthritis. Br Med J. 1970 Jan 3;1(5687):24–25. doi: 10.1136/bmj.1.5687.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DINTENFASS L. LUBRICATION IN SYNOVIAL JOINTS: A THEORETICAL ANALYSIS. J Bone Joint Surg Am. 1963 Sep;45:1241–1256. [PubMed] [Google Scholar]
- Helal B., Karadi B. S. Artificial lubrication of joints: use of silicone oil. Ann Phys Med. 1968 Nov;9(8):334–340. doi: 10.1093/rheumatology/9.8.334. [DOI] [PubMed] [Google Scholar]
- Nuki G., Ferguson J., Boyle J. A., Boddy K. Rheological simulation of synovial fluid by a synthetic polymer solution. Nature. 1969 Dec 13;224(5224):1118–1119. doi: 10.1038/2241118a0. [DOI] [PubMed] [Google Scholar]
- Shah K. D., Wright V. Intra-articular hydrocortisone in osteo-arthrosis. Ann Rheum Dis. 1967 Jul;26(4):316–318. doi: 10.1136/ard.26.4.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tanner R. I. An alternative mechanism for the lubrication of synovial joints. Phys Med Biol. 1966 Jan;11(1):119–127. doi: 10.1088/0031-9155/11/1/312. [DOI] [PubMed] [Google Scholar]