Skip to main content
NCBI home page
British Medical Journal logoLink to British Medical Journal
. 1971 Jun 5;2(5761):552–554. doi: 10.1136/bmj.2.5761.552

Red Cell Sodium in Hyperthyroidism

A W G Goolden, Diana Bateman, Susan Torr
PMCID: PMC1795816  PMID: 5579190

Abstract

A simple method of measuring red cell sodium has shown that about 90% of thyrotoxic patients have values above the upper limit of the normal range. Patients taking 0·3 mg of L-thyroxine daily were found to have a significantly higher mean value for red cell sodium than that of the normal controls. It is suggested that patients taking this amount of thyroxine may be hypermetabolic. The determination of red cell sodium may prove useful as a measure of the peripheral action of thyroid hormone.

Full text

PDF
552

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AWWAD H. K., GOOLDEN A. W. The uptake of radioactive potassium by red cells in various thyroid states. Clin Sci. 1961 Feb;20:113–122. [PubMed] [Google Scholar]
  2. BOEKELMAN W. A. Sodium content of erythrocytes in hyperthyroidism. Nature. 1958 Apr 19;181(4616):1136–1136. doi: 10.1038/1811136a0. [DOI] [PubMed] [Google Scholar]
  3. Beilin L. J., Knight G. J., Munro-Faure A. D., Anderson J. The sodium, potassium, and water contents of red blood cells of healthy human adults. J Clin Invest. 1966 Nov;45(11):1817–1825. doi: 10.1172/JCI105485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Braverman L. E., Ingbar S. H., Sterling K. Conversion of thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects. J Clin Invest. 1970 May;49(5):855–864. doi: 10.1172/JCI106304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CHAPLIN H., Jr, MOLLISON P. L. Correction for plasma trapped in the red cell column of the hematocrit. Blood. 1952 Dec;7(12):1227–1238. [PubMed] [Google Scholar]
  6. DOWBEN R. M., HOLLEY K. R. Erythrocyte electrolytes in muscle disease. J Lab Clin Med. 1959 Dec;54:867–870. [PubMed] [Google Scholar]
  7. Funder J., Wieth J. O. Potassium, sodium, and water in normal human red blood cells. Scand J Clin Lab Invest. 1966;18(2):167–180. doi: 10.3109/00365516609051812. [DOI] [PubMed] [Google Scholar]
  8. Gimlette T. M. Use of Sephadex column chromatography in the assessment of thyroid status. J Clin Pathol. 1967 Mar;20(2):170–174. doi: 10.1136/jcp.20.2.170. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hoffman J. F. The red cell membrane and the transport of sodium and potassium. Am J Med. 1966 Nov;41(5):666–680. doi: 10.1016/0002-9343(66)90029-5. [DOI] [PubMed] [Google Scholar]
  10. OSORIO C., JACKSON D. J., GARTSIDE J. M., GOOLDEN A. W. The assessment of free thyroxine in plasma. Clin Sci. 1962 Dec;23:525–530. [PubMed] [Google Scholar]
  11. Smith E. K., Samuel P. D. Abnormalities in the sodium pump of erythrocytes from patients with hyperthyroidism. Clin Sci. 1970 Jan;38(1):49–61. doi: 10.1042/cs0380049. [DOI] [PubMed] [Google Scholar]
  12. VALBERG L. S., HOLT J. M., PAULSON E., SZIVEK J. SPECTROCHEMICAL ANALYSIS OF SODIUM, POTASSIUM, CALCIUM, MAGNESIUM, COPPER, AND ZINC IN NORMAL HUMAN ERYTHROCYTES. J Clin Invest. 1965 Mar;44:379–389. doi: 10.1172/JCI105151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. WELT L. G., SACHS J. R., MCMANUS T. J. AN ION TRANSPORT DEFECT IN ERYTHROCYTES FROM UREMIC PATIENTS. Trans Assoc Am Physicians. 1964;77:169–181. [PubMed] [Google Scholar]
  14. de Garreta A. C., Fisicas C. S., Glass H. I., Goolden A. W. Measurement of the uptake of 99mTc by the thyroid. Br J Radiol. 1968 Dec;41(492):896–898. doi: 10.1259/0007-1285-41-492-896. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES