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. 1971 Jun 26;2(5764):739–741. doi: 10.1136/bmj.2.5764.739

Potassium-sparing Agents during Diuretic Therapy in Hypertension

T J McKenna, J F Donohoe, T G Brien, J J Healy, B St J Canning, F P Muldowney
PMCID: PMC1796357  PMID: 5090761

Abstract

Three pharmacological agents in use as “potassium-sparing” drugs have been tested by serial measurements of total exchangeable potassium (KE) during 4 to 12 weeks of oral diuretic therapy in hypertensive subjects. Triamterene seemed ineffective in the dosage used (50 mg twice daily). Spironolactone (25 mg twice daily) reduced K loss to a considerable extent, while Slow-K (32 mEq daily) completely reversed previous KE deficits. Plasma K levels were a poor indication of degree of KE restoration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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