Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1971 May 1;2(5756):252–255. doi: 10.1136/bmj.2.5756.252

Radioselenium in Duodenal Aspirate as an Assessment of Pancreatic Exocrine Function*

G R Youngs, J E Agnew, G E Levin, I A D Bouchier
PMCID: PMC1796423  PMID: 5572384

Abstract

A new test of pancreatic exocrine function is described in which radioselenium is measured in duodenal aspirate after an intravenous injection of 75Se-selenomethionine and administration of a Lundh test meal. Duodenal 75Se activity gave good separation between normals and subjects with disease of the exocrine pancreas and correlated well with trypsin levels in the aspirate.

Full text

PDF
252

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLFREY V., DALY M. M., MIRSKY A. E. Synthesis of protein in the pancreas. II. The role of ribonucleoprotein in protein synthesis. J Gen Physiol. 1953 Nov 20;37(2):157–175. doi: 10.1085/jgp.37.2.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Charlesworth D., Testa H. J., Pullan B. R., Torrance B. Radio-isotope scanning in the diagnosis of pancreatic disease. Br J Surg. 1970 Jun;57(6):413–417. doi: 10.1002/bjs.1800570604. [DOI] [PubMed] [Google Scholar]
  3. Cook H. B., Lennard-Jones J. E., Sherif S. M., Wiggins H. S. Measurement of tryptic activity in intestinal juice as a diagnostic test of pancreatic disease. Gut. 1967 Aug;8(4):408–414. doi: 10.1136/gut.8.4.408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cooke A. R., Nahrwold D. L., Grossman M. I. Diversion of pancreatic juice on gastric and pancreatic response to a meal stimulus. Am J Physiol. 1967 Sep;213(3):637–639. doi: 10.1152/ajplegacy.1967.213.3.637. [DOI] [PubMed] [Google Scholar]
  5. HANSSON E., BLAU M. INCORPORATION OF SE75-SELENOMETHIONINE INTO PANCREATIC JUICE PROTEINS IN VIVO. Biochem Biophys Res Commun. 1963 Sep 10;13:71–74. doi: 10.1016/0006-291x(63)90165-7. [DOI] [PubMed] [Google Scholar]
  6. JUNQUEIRA L. C., HIRSCH G. C., ROTHSCHILD H. A. Glycine uptake by the proteins of the rat pancreatic juice. Biochem J. 1955 Oct;61(2):275–278. doi: 10.1042/bj0610275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. KELLER P. J., COHEN E., NEURATH H. The proteins of bovine pancreatic juice. J Biol Chem. 1958 Aug;233(2):344–349. [PubMed] [Google Scholar]
  8. LUNDH G. Pancreatic exocrine function in neoplastic and inflammatory disease; a simple and reliable new test. Gastroenterology. 1962 Mar;42:275–280. [PubMed] [Google Scholar]
  9. Melmed R. N., Agnew J. E., Bouchier I. A. The normal and abnormal pancreatic scan. Q J Med. 1968 Oct;37(148):607–624. [PubMed] [Google Scholar]
  10. Qawwad H. K., Potchen E. J., Adelstein S. J., Dealy J. B., Jr Se75-selenomethionine incorporation into human plasma proteins and erythrocytes. Metabolism. 1966 Jul;15(7):626–640. doi: 10.1016/0026-0495(66)90124-7. [DOI] [PubMed] [Google Scholar]
  11. SPENCER R. P., BLAU M. Intestinal transport of selenium-75 selenomethionine. Science. 1962 Apr 13;136(3511):155–156. doi: 10.1126/science.136.3511.155. [DOI] [PubMed] [Google Scholar]
  12. Silberberg V. L., Hadorn B. Identification of pancreatic enzymes in human duodenal contents. Biochim Biophys Acta. 1968 Nov 19;167(3):616–619. doi: 10.1016/0005-2744(68)90054-5. [DOI] [PubMed] [Google Scholar]
  13. Sodee D. B. Pancreatic scanning. Radiology. 1966 Oct;87(4):641–645. doi: 10.1148/87.4.641. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES