Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1971 Jul 24;3(5768):215–217. doi: 10.1136/bmj.3.5768.215

Comparative Double-blind Trial of Cephalexin and Ampicillin in Treatment of Urinary Infections

J A Davies, J E M Strangeways, R G Mitchell, L J Beilin, J G G Ledingham, J M Holt
PMCID: PMC1798560  PMID: 4934374

Abstract

Cephalexin was compared with ampicillin in the treatment of urinary tract infections by a random double-blind technique. Both drugs were found to be equally effective. In 21 out of 31 patients treated with cephalexin and in 20 out of 31 treated with ampicillin the urine was sterile three weeks after starting therapy. The bacteriological findings at one and eight weeks were also similar in both groups. No serious adverse reactions were attributable to cephalexin, which seemed to be tolerated rather better than ampicillin.

Full text

PDF
215

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON K. N., KENNEDY R. P., PLORDE J. J., SHULMAN J. A., PETERSDORF R. G. EFFECTIVENESS OF AMPICILLIN AGAINST GRAM-NEGATIVE BACTERIA. IN VITRO AND IN VIVO STUDIES OF A NEW ANTIBIOTIC. JAMA. 1964 Feb 22;187:555–561. [PubMed] [Google Scholar]
  2. Gower P. E., Dash C. H. Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic. Br J Pharmacol. 1969 Nov;37(3):738–747. doi: 10.1111/j.1476-5381.1969.tb08513.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Meyers B. R., Kaplan K., Weinstein L. Cephalexin: microbiological effects and pharmacologic parameters in man. Clin Pharmacol Ther. 1969 Nov-Dec;10(6):810–816. doi: 10.1002/cpt1969106810. [DOI] [PubMed] [Google Scholar]
  4. Perkins R. L., Carlisle H. N., Saslaw S. Cephalexin: in vitro bacterial susceptibility, absorption in volunteers, and antibacterial activity of sera and urine. Am J Med Sci. 1968 Aug;256(2):122–129. [PubMed] [Google Scholar]
  5. Reeves D. S., Faiers M. C., Pursell R. E., Brumfitt W. Trimethoprim--sulphamethoxazole: comparative study in urinary infection in hospital. Br Med J. 1969 Mar 1;1(5643):541–544. doi: 10.1136/bmj.1.5643.541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Wick W. E. Cephalexin, a new orally absorbed cephalosporin antibiotic. Appl Microbiol. 1967 Jul;15(4):765–769. doi: 10.1128/am.15.4.765-769.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES