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. 1971 Jul 31;3(5769):287–290. doi: 10.1136/bmj.3.5769.287

Controlled Comparison of the Efficacy of Fourteen Preparations in the Relief of Postoperative Pain

J D Morrison, W B Loan, J W Dundee
PMCID: PMC1799136  PMID: 4934047

Abstract

Thirteen analgesic drugs, four of them at two dose levels, four analgesics in combination with antagonist or neuroleptic agents, and saline have been evaluated simultaneously in the relief of postoperative pain. The method of assessment was designed to favour drugs which provided freedom from pain with minimum depression of consciousness. Only levorphanol 2 mg proved significantly superior to pethidine 100 mg, which was used as the standard reference drug. Oxycodone 10 mg, pentazocine 20 mg, and the morphine 10 mg and cyclizine 50 mg combination were the most successful of the remaining drugs. None of the drug combinations was significantly better than the analgesic drug given alone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRITTAIN G. J. Dihydrohydroxycodeinone pectinate. Lancet. 1959 Oct 10;2(7102):544–546. doi: 10.1016/s0140-6736(59)91781-7. [DOI] [PubMed] [Google Scholar]
  2. BROMAGE P. R. Spirometry in assessment of analgesia after abdominal surgery; a method of comparing analgesic drugs. Br Med J. 1955 Sep 3;2(4939):589–593. doi: 10.1136/bmj.2.4939.589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BROWN A. K. Levorphan in anaesthesia. Br Med J. 1954 Oct 23;2(4894):967–969. doi: 10.1136/bmj.2.4894.967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Conaghan J. P., Jacobsen M., Rae L., Ward-McQuaid J. N. Pentazocine and phenazocine. A double-blind comparison of two benzomorphan derivatives in postoperative pain. Br J Anaesth. 1966 May;38(5):345–354. doi: 10.1093/bja/38.5.345. [DOI] [PubMed] [Google Scholar]
  5. Dundee J. W., Gray R. C. Sympathetic overactivity in tetanus. Lancet. 1969 Apr 12;1(7598):779–780. doi: 10.1016/s0140-6736(69)91783-8. [DOI] [PubMed] [Google Scholar]
  6. Dundee J. W., Loan W. B., Morrison J. D. Studies of drugs given before anaesthesia. XIX. The opiates. Br J Anaesth. 1970 Jan;42(1):54–58. doi: 10.1093/bja/42.1.54. [DOI] [PubMed] [Google Scholar]
  7. EDDY N. B., HALBACH H., BRAENDEN O. J. Synthetic substances with morphine-like effect: clinical experience; potency, side-effects, addiction liability. Bull World Health Organ. 1957;17(4-5):569–863. [PMC free article] [PubMed] [Google Scholar]
  8. Finch J. S., DeKornfeld T. J. Clinical investigation of the analgesic potency and respiratory depressant activity of fentanyl, a new narcotic analgesic. J Clin Pharmacol J New Drugs. 1967 Jan-Feb;7(1):46–51. doi: 10.1002/j.1552-4604.1967.tb00029.x. [DOI] [PubMed] [Google Scholar]
  9. GLAZEBROOK A. J. Actions and uses of methorphinan. Br Med J. 1952 Dec 20;2(4798):1328–1330. doi: 10.1136/bmj.2.4798.1328. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HUNT R. D., FOLDES F. F. The use of levo-dromoran tartrate (levorphan tartrate) for relief of postoperative pain. N Engl J Med. 1953 May 7;248(19):803–805. doi: 10.1056/NEJM195305072481902. [DOI] [PubMed] [Google Scholar]
  11. KEATS A. S., TELFORD J. STUDIES OF ANALGESIC DRUGS. VIII. A NARCOTIC ANTAGONIST ANALGESIC WITHOUT PSYCHOTOMIMETIC EFFECTS. J Pharmacol Exp Ther. 1964 Feb;143:157–164. [PubMed] [Google Scholar]
  12. LASAGNA L. THE CLINICAL EVALUATION OF MORPHINE AND ITS SUBSTITUTES AS ANALGESICS. Pharmacol Rev. 1964 Mar;16:47–83. [PubMed] [Google Scholar]
  13. Loan W. B., Dundee J. W., Clarke R. S. Studies of drugs given before anaesthesia. XII. A comparison of papaveretum and morphine. Br J Anaesth. 1966 Nov;38(11):891–900. doi: 10.1093/bja/38.11.891. [DOI] [PubMed] [Google Scholar]
  14. Loan W. B., Morrison J. D., Dundee J. W., Clarke R. S., Hamilton R. C., Brown S. S. Studies of drugs given before anaesthesia. XVII: The natural and semi-synthetic opiates. Br J Anaesth. 1969 Jan;41(1):57–63. doi: 10.1093/bja/41.1.57. [DOI] [PubMed] [Google Scholar]
  15. Loan W. B., Morrison J. D., Dundee J. W. Evaluation of a method for assessing potent analgesics. Clin Pharmacol Ther. 1968 Nov-Dec;9(6):765–776. doi: 10.1002/cpt196896765. [DOI] [PubMed] [Google Scholar]
  16. MASSON A. H. Clinical assessment of analgesic drugs: spirometry trial. Anesth Analg. 1962 Sep-Oct;41:615–622. [PubMed] [Google Scholar]
  17. Morrison J. D. Alterations in response to somatic pain associated with anaesthesia. XIX: Studies with the drugs used in neuroleptanaesthesia. Br J Anaesth. 1970 Oct;42(10):838–848. doi: 10.1093/bja/42.10.838. [DOI] [PubMed] [Google Scholar]
  18. Morrison J. D., Loan W. B., Dundee J. W., McDowell S. A., Brown S. S. Studies of drugs given before anaesthesia. 18. The synthetic opiates. Br J Anaesth. 1969 Nov;41(11):987–993. doi: 10.1093/bja/41.11.987. [DOI] [PubMed] [Google Scholar]
  19. TELFORD J., KEATS A. S. Narcotic--narcotic antagonist mixtures. Anesthesiology. 1961 May-Jun;22:465–484. doi: 10.1097/00000542-196105000-00021. [DOI] [PubMed] [Google Scholar]

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