Abstract
The concentrations of ceftazidime in the serum and cerebrospinal fluid of patients with and without meningitis were measured at various times after a 2- or 3-g dose. At similar concentrations in serum, ceftazidime concentrations in cerebrospinal fluid at a given time were substantially lower in patients without meningitis (mean, 0.8 micrograms/ml) than in those with meningitis (mean, 22.6 micrograms/ml).
Full text
PDF

Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barling R. W., Selkon J. B. The penetration of antibiotics into cerebrospinal fluid and brain tissue. J Antimicrob Chemother. 1978 May;4(3):203–227. doi: 10.1093/jac/4.3.203. [DOI] [PubMed] [Google Scholar]
- Modai J., Vittecoq D., Decazes J. M., Wolff M., Meulemans A. Penetration of ceftazidime into cerebrospinal fluid of patients with bacterial meningitis. Antimicrob Agents Chemother. 1983 Jul;24(1):126–128. doi: 10.1128/aac.24.1.126. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Myers C. M., Blumer J. L. Determination of ceftazidime in biological fluids by using high-pressure liquid chromatography. Antimicrob Agents Chemother. 1983 Sep;24(3):343–346. doi: 10.1128/aac.24.3.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Norrby S. R. Ceftazidime in clinical practice - a summary. J Antimicrob Chemother. 1983 Jul;12 (Suppl A):405–408. doi: 10.1093/jac/12.suppl_a.405. [DOI] [PubMed] [Google Scholar]