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. 1984 Oct;26(4):450–454. doi: 10.1128/aac.26.4.450

Interferon aerosol suppression of vesicular stomatitis virus replication in the lungs of infected mice.

P R Wyde, S Z Wilson, C S Sun, V Knight
PMCID: PMC179943  PMID: 6097164

Abstract

Mice were inoculated intranasally with vesicular stomatitis virus 16 to 22 h after being exposed to small-particle aerosols of saline, natural mouse alpha interferon, recombinant human alpha interferon A, or hybrid recombinant human alpha interferon A/D bgl for 2, 4, or 8 h. Compared with comparably inoculated, untreated mice, significantly reduced levels of vesicular stomatitis virus were observed in the lungs of animals treated with any interferon preparation for 8 h and in groups treated with mouse alpha interferon or hybrid recombinant human alpha interferon A/D bgl for 4 h. No significant reductions in lung virus titers were observed in any group treated with interferon for 2 h or in any of the groups treated with saline.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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