Abstract
The in vitro activities of the new spectinomycin analog U-63366 and four new quinolone derivatives, rosoxacin, norfloxacin, ofloxacin, and ciprofloxacin, were compared with those of penicillin, tetracycline, thiamphenicol, cefotaxime, ceftriaxone, and spectinomycin against 222 beta-lactamase-negative and 25 beta-lactamase-positive Neisseria gonorrhoeae strains. U-63366 was more active than spectinomycin, inhibiting 90% of the strains at a concentration of 2 mg/liter. Among the quinolone derivatives, ciprofloxacin was the most active compound in vitro (90% MIC, 0.002 mg/liter), followed by ofloxacin (90% MIC, 0.008 mg/liter), norfloxacin (90% MIC, 0.015 mg/liter), and rosoxacin (90% MIC, 0.03 mg/liter).
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- Ashford W. A., Potts D. W., Adams H. J., English J. C., Johnson S. R., Biddle J. W., Thornsberry C., Jaffe H. W. Spectinomycin-resistant penicillinase-producing Neisseria gonorrhoeae. Lancet. 1981 Nov 7;2(8254):1035–1037. doi: 10.1016/s0140-6736(81)91227-7. [DOI] [PubMed] [Google Scholar]
- Bonati M., Tognoni G. Has clinical pharmacology lost its way? Lancet. 1984 Mar 10;1(8376):556–558. doi: 10.1016/s0140-6736(84)90945-0. [DOI] [PubMed] [Google Scholar]
- Boppana V. K., Swanson B. N. Determination of norfloxacin, a new nalidixic acid analog, in human serum and urine by high-performance liquid chromatography. Antimicrob Agents Chemother. 1982 May;21(5):808–810. doi: 10.1128/aac.21.5.808. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Calubiran O. V., Crisologo-Vizconde L. B., Tupasi T. E., Torres C. A., Limson B. M. Treatment of uncomplicated gonorrhoea in women. Comparison of rosoxacin and spectinomycin. Br J Vener Dis. 1982 Aug;58(4):231–235. doi: 10.1136/sti.58.4.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cohen A. I., Rein M. F., Noble R. C. A comparison of rosoxacin with ampicillin and probenecid in the treatment of uncomplicated gonorrhea. Sex Transm Dis. 1984 Jan-Mar;11(1):24–27. doi: 10.1097/00007435-198401000-00005. [DOI] [PubMed] [Google Scholar]
- Crump B., Wise R., Dent J. Pharmacokinetics and tissue penetration of ciprofloxacin. Antimicrob Agents Chemother. 1983 Nov;24(5):784–786. doi: 10.1128/aac.24.5.784. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Handsfield H. H., Judson F. N., Holmes K. K. Treatment of uncomplicated gonorrhea with rosoxacin. Antimicrob Agents Chemother. 1981 Nov;20(5):625–629. doi: 10.1128/aac.20.5.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Khan M. Y., Siddiqui Y., Gruninger R. P. Comparative in vitro activity of Mk-0366 and other selected oral antimicrobial agents against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1981 Aug;20(2):265–266. doi: 10.1128/aac.20.2.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Callaghan C. H., Morris A., Kirby S. M., Shingler A. H. Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate. Antimicrob Agents Chemother. 1972 Apr;1(4):283–288. doi: 10.1128/aac.1.4.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sanders C. C. Novel resistance selected by the new expanded-spectrum cephalosporins: a concern. J Infect Dis. 1983 Mar;147(3):585–589. doi: 10.1093/infdis/147.3.585. [DOI] [PubMed] [Google Scholar]
- Wise R., Andrews J. M., Edwards L. J. In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agents. Antimicrob Agents Chemother. 1983 Apr;23(4):559–564. doi: 10.1128/aac.23.4.559. [DOI] [PMC free article] [PubMed] [Google Scholar]
- de Hoop D., Nayyar K. C., van Klingeren B., Stolz E., Michel M. F. Infections with non-penicillinase-producing Neisseria gonorrhoeae treated with cefuroxime: treatment failures. Sex Transm Dis. 1982 Oct-Dec;9(4):200–201. doi: 10.1097/00007435-198210000-00007. [DOI] [PubMed] [Google Scholar]