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. 1971 Nov 27;4(5786):516–518. doi: 10.1136/bmj.4.5786.516

Coagulation Defects in Hypoxic Full-term Newborn Infants

M A Chadd, P C Elwood, O P Gray, S M Muxworthy
PMCID: PMC1799783  PMID: 5126955

Abstract

Blood clotting was examined in 24 consecutive full-term newborn infants with hypoxia and 23 normal control infants. There was evidence of a gross alteration in the clotting process in the hypoxic infants. The degree of disturbance in clotting seemed to be dependent on the severity of the hypoxia, suggesting a causal relationship. The mechanism involved seemed to be intravascular coagulation. The consumption of clotting factors involved led to the appearance of a haemorrhagic diathesis. This effect seemed to be of short duration, suggesting that direct liver damage plays at most a minor part.

Though there was no evidence of damage in the infants who survived, it is possible that intravascular coagulation induced by hypoxia, by leading to deposition of fibrin, may cause damage to vital organs. Further studies will be required to examine this possibility.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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