Abstract
The pharmacokinetics of cefotiam were studied after a single intravenous 1.0-g dose to 18 subjects grouped according to their creatinine clearances (CLCR); CLCR was above 75, 75 to 20, and below 20 ml/min per 1.73 m2 in groups 1, 2, and 3, respectively. Cefotiam obeyed two-compartment model kinetics in all three groups. The volume of distribution based on the area under serum concentration-time curve (Varea) was renal function independent, the average value being 0.350 +/- 0.159 liters/kg. The elimination-phase half-life (t1/2 beta) was 0.916 +/- 0.090 h in group 1, 2.03 +/- 1.62 h in group 2, and 7.09 +/- 3.06 h in group 3. Cumulative 24-h urinary excretion accounted for 65 to 93% of the dose in four subjects with CLCRS above 80 ml/min per 1.73 m2 and 19 to 41% in three subjects with CLCRS below 20 ml/min per 1.73 m2. We give recommendations for dosage adjustment in patients with renal insufficiency. The effect of hemodialysis on cefotiam pharmacokinetics was studied in six patients in end-stage renal failure; hemodialysis shortened the average t1/2 beta from 8.02 +/- 4.04 h to 2.74 +/- 2.15 h. We estimated that in a hypothetical anephric patient with a body weight of 60 kg, 6-h hemodialysis would remove 49.7% of the drug present in the body at the start of dialysis.
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- Bolton W. K., Scheld W. M., Spyker D. A., Overby T. L., Sande M. A. Pharmacokinetics of moxalactam in subjects with various degrees of renal dysfunction. Antimicrob Agents Chemother. 1980 Dec;18(6):933–938. doi: 10.1128/aac.18.6.933. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brogard J. M., Comte F. Pharmacokinetics of the new cephalosporins. Antibiot Chemother (1971) 1982;31:145–210. doi: 10.1159/000400133. [DOI] [PubMed] [Google Scholar]
- Brogard J. M., Comte F., Pinget M. Pharmacokinetics of cephalosporin antibiotics. Antibiot Chemother (1971) 1978;25:123–162. doi: 10.1159/000401060. [DOI] [PubMed] [Google Scholar]
- Daschner F. D., Hemmer K. A., Offermann P., Slanicka J. Pharmacokinetics of cefotiam in normal humans. Antimicrob Agents Chemother. 1982 Dec;22(6):958–960. doi: 10.1128/aac.22.6.958. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lam M., Manion C. V., Czerwinski A. W. Pharmacokinetics of moxalactam in patients with renal insufficiency. Antimicrob Agents Chemother. 1981 Mar;19(3):461–464. doi: 10.1128/aac.19.3.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Milutinovic J., Cutler R. E., Hoover P., Meijsen B., Scribner B. H. Measurement of residual glomerular filtration rate in the patient receiving repetitive hemodialysis. Kidney Int. 1975 Sep;8(3):185–190. doi: 10.1038/ki.1975.98. [DOI] [PubMed] [Google Scholar]