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. 1971 Dec 4;4(5787):584–586. doi: 10.1136/bmj.4.5787.584

Transience of Immune Responses to Tumour Antigens in Man

J L Odili, Geoffrey Taylor
PMCID: PMC1799950  PMID: 4943215

Abstract

By examining serial serum samples from patients undergoing surgical removal of malignant tumours an increased incidence of tumour-specific antibodies has been detected. Antibody responses to tumour neoantigens seem to be transient, and this is held to account for the rarity of detections where a single sample of serum is examined.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander P. Prospects for immunotherapy of cancer: experience in experimental systems. Br Med J. 1970 Nov 21;4(5733):484–486. doi: 10.1136/bmj.4.5733.484. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Dore J. F., Motta R., Marholev L., Hrsak I., Colas de la Noue H., Seman G., De Vassal F., Mathé G. New antigens in human leukaemic cells and antibody in the serum of leukaemic patients. Lancet. 1967 Dec 30;2(7531):1396–1398. doi: 10.1016/s0140-6736(67)93027-9. [DOI] [PubMed] [Google Scholar]
  3. Fairley G. H. Evidence for antigenicity in human tumours with reference to both melanoma and acute leukaemia. Br Med J. 1970 Nov 21;4(5733):483–484. doi: 10.1136/bmj.4.5733.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fairley G. H. Immunity to malignant disease in man. Br Med J. 1969 May 24;2(5655):467–473. doi: 10.1136/bmj.2.5655.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GRAHAM J. B., GRAHAM R. M. Antibodies elicited by cancer in patients. Cancer. 1955 Mar-Apr;8(2):409–416. doi: 10.1002/1097-0142(1955)8:2<409::aid-cncr2820080221>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  6. Gold P., Freedman S. O. Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 1965 Sep 1;122(3):467–481. doi: 10.1084/jem.122.3.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hodkinson M., Taylor G. Autoimmune responses to human tumour antigens. Br J Cancer. 1969 Sep;23(3):510–514. doi: 10.1038/bjc.1969.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ikonopisov R. L., Lewis M. G., Hunter-Craig I. D., Bodenham D. C., Phillips T. M., Cooling C. I., Proctor J., Fairley G. H., Alexander P. Autoimmunization with irradiated tumour cells in human malignant melanoma. Br Med J. 1970 Jun 27;2(5712):752–754. doi: 10.1136/bmj.2.5712.752. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Klein G. Immunological factors affecting tumour growth. Br Med J. 1970 Nov 14;4(5732):418–418. doi: 10.1136/bmj.4.5732.418. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lewis M. G., Ikonopisov R. L., Nairn R. C., Phillips T. M., Fairley G. H., Bodenham D. C., Alexander P. Tumour-specific antibodies in human malignant melanoma and their relationship to the extent of the disease. Br Med J. 1969 Sep 6;3(5670):547–552. doi: 10.1136/bmj.3.5670.547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lewis M. G. Possible immunological factors in human malignant melanoma in Uganda. Lancet. 1967 Oct 28;2(7522):921–922. doi: 10.1016/s0140-6736(67)90236-x. [DOI] [PubMed] [Google Scholar]
  12. Mathé G. Approaches to the immunological treatment of cancer in man. Br Med J. 1969 Oct 4;4(5674):7–10. doi: 10.1136/bmj.4.5674.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mathé G. Immunological treatment of leukaemias. Br Med J. 1970 Nov 21;4(5733):487–488. doi: 10.1136/bmj.4.5733.487. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Southam C. M. Evidence of immunological reactions to autochthonous cancer in man. Eur J Cancer. 1965 Nov;1(3):173–181. doi: 10.1016/0014-2964(65)90045-9. [DOI] [PubMed] [Google Scholar]
  15. Taylor G., Odili J. L. Tumour specific T-like antigen of human breast carcinoma. Br J Cancer. 1970 Sep;24(3):447–453. doi: 10.1038/bjc.1970.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Woodruff M. Immunotherapy of cancer. Br Med J. 1970 Nov 21;4(5733):486–487. doi: 10.1136/bmj.4.5733.486. [DOI] [PMC free article] [PubMed] [Google Scholar]

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