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. 1971 Jul 3;3(5765):25–27. doi: 10.1136/bmj.3.5765.25

Combined Use of Clofibrate and Cholestyramine or DEAE Sephadex in Hypercholesterolaemia

A N Howard, D E Hyams
PMCID: PMC1800097  PMID: 4933388

Abstract

A comparison was made of the effect of DEAE (diethylaminoethyl) Sephadex (an anion exchange resin) and cholestyramine (Questran) with and without the addition of clofibrate in normal and hypercholesterolaemic patients. DEAE Sephadex (12-15 g/day) alone appeared to be as effective as cholestyramine in lowering the plasma cholesterol by 12-15%. Clofibrate acted synergistically with DEAE Sephadex and increased the activity of the latter by over twofold. This combination proved superior to that of clofibrate and cholestyramine and has the greatest potential use in the treatment of type II pattern hyperlipoproteinaemia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fredrickson D. S., Levy R. I., Lees R. S. Fat transport in lipoproteins--an integrated approach to mechanisms and disorders. N Engl J Med. 1967 Jan 19;276(3):148–contd. doi: 10.1056/NEJM196701192760305. [DOI] [PubMed] [Google Scholar]
  2. Goodman D. S., Noble R. P. Turnover of plasma cholesterol in man. J Clin Invest. 1968 Feb;47(2):231–241. doi: 10.1172/JCI105719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HASHIM S. A., VANITALLIE T. B. CHOLESTYRAMINE RESIN THERAPY FOR HYPERCHOLESTEREMIA: CLINICAL AND METABOLIC STUDIES. JAMA. 1965 Apr 26;192:289–293. doi: 10.1001/jama.1965.03080170017004. [DOI] [PubMed] [Google Scholar]
  4. LOFLAND H. B., Jr A SEMIAUTOMATED PROCEDURE FOR THE DETERMINATION OF TRIGLYCERIDES IN SERUM. Anal Biochem. 1964 Dec;9:393–400. doi: 10.1016/0003-2697(64)90199-x. [DOI] [PubMed] [Google Scholar]
  5. Parkinson T. M. Hypolipidemic effects of orally administered dextran and cellulose anion exchangers in cockerels and dogs. J Lipid Res. 1967 Jan;8(1):24–29. [PubMed] [Google Scholar]
  6. SPERRY W. M., WEBB M. A revision of the Schoenheimer-Sperry method for cholesterol determination. J Biol Chem. 1950 Nov;187(1):97–106. [PubMed] [Google Scholar]

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