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. 1984 Nov;26(5):766–769. doi: 10.1128/aac.26.5.766

Prospective randomized double-blind comparison of nephrotoxicity and auditory toxicity of tobramycin and netilmicin.

J M Gatell, J G SanMiguel, V Araujo, L Zamora, J Maña, M Ferrer, M Bonet, M Bohe, M T Jimenez de Anta
PMCID: PMC180010  PMID: 6393868

Abstract

Netilmicin or tobramycin was administered to 197 patients in a prospective randomized double-blind trial. Of these patients, 140 recipients of nine or more doses of netilmicin or tobramycin could be evaluated for nephrotoxicity. Fifty-five patients were able to cooperate in the administration of serial audiograms. Nephrotoxicity of similar severity developed in 7 of 73 (9.6%) recipients of tobramycin and in 7 of 67 (10.4%) recipients of netilmicin (P greater than 0.05). Mild or slight auditory toxicity developed in 5 of 28 (17.8%) recipients of tobramycin and in 2 of 27 (7.4%) recipients of netilmicin (P greater than 0.05).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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