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. 1984 Dec;26(6):863–869. doi: 10.1128/aac.26.6.863

Gastrointestinal motor-stimulating activity of macrolide antibiotics and analysis of their side effects on the canine gut.

Z Itoh, T Suzuki, M Nakaya, M Inoue, S Mitsuhashi
PMCID: PMC180040  PMID: 6524902

Abstract

For clarification of the nature of the side effects of macrolide antibiotics on the gastrointestinal tract, the motor-stimulating activity of these agents was studied in unanesthetized dogs. The results showed that erythromycin and oleandomycin, the 14-membered macrolides with two side chain sugars combined at C3 and C5 in a glycosidic linkage in parallel, strongly stimulate gastrointestinal motor activity, an action accompanied by vomiting at large doses. On the other hand, leucomycin, acetylspiramycin, and tylosin, belonging to a 16-membered macrolide with two side chain sugars in series combined at C5 of the lactone ring, did not induce contractions of the gastrointestinal tract. Motor-stimulating activity by erythromycin and oleandomycin was greatly inhibited by atropine sulfate. These results point to structure-physiological activity relationships.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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