Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1984 Dec;26(6):881–886. doi: 10.1128/aac.26.6.881

In vitro activity and human pharmacokinetics of teicoplanin.

L Verbist, B Tjandramaga, B Hendrickx, A Van Hecken, P Van Melle, R Verbesselt, J Verhaegen, P J De Schepper
PMCID: PMC180043  PMID: 6240962

Abstract

The in vitro activity of teicoplanin, a new antibiotic related to vancomycin, was determined against 456 gram-positive cocci. The activity of teicoplanin in comparison with that of vancomycin was similar against staphylococci but 4 to 40 times higher against enterococci and beta-hemolytic and viridans streptococci. The single-dose pharmacokinetics of teicoplanin were studied in six healthy volunteers after administration of 3 and 6 mg/kg intravenously and of 3 mg/kg intramuscularly. The kinetic parameters after both intravenous doses were very similar. The curves for concentration in plasma for the 3- and 6-mg/kg intravenous doses showed a triexponential decline with elimination half-lives of 47.3 and 44.1 h, respectively. The percentages of the doses recovered in urine (0 to 102 h) were 43.2 and 44.1%, respectively. The areas under the plasma curves were dose related: 256.5 and 520.9 micrograms/h per ml, respectively. The bioavailability of teicoplanin after injection of 3 mg/kg intramuscularly was 90%, and the peak level was 7.1 micrograms/ml. The mean levels in plasma 24 h after the 3-mg/kg doses were 2.1 and 2.3 micrograms/ml, respectively, and the mean level in plasma 24 h after the 6-mg/kg intravenous dose was 4.2 micrograms/ml.

Full text

PDF
881

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bardone M. R., Paternoster M., Coronelli C. Teichomycins, new antibiotics from Actinoplanes teichomyceticus nov. sp. II. Extraction and chemical characterization. J Antibiot (Tokyo) 1978 Mar;31(3):170–177. doi: 10.7164/antibiotics.31.170. [DOI] [PubMed] [Google Scholar]
  2. Bauernfeind A., Petermüller C. In vitro activity of teichomycin A 2 in comparison with penicillin and vancomycin against gram-positive cocci. Eur J Clin Microbiol. 1982 Oct;1(5):278–281. doi: 10.1007/BF02019971. [DOI] [PubMed] [Google Scholar]
  3. Benet L. Z., Galeazzi R. L. Noncompartmental determination of the steady-state volume of distribution. J Pharm Sci. 1979 Aug;68(8):1071–1074. doi: 10.1002/jps.2600680845. [DOI] [PubMed] [Google Scholar]
  4. Blouin R. A., Bauer L. A., Miller D. D., Record K. E., Griffen W. O., Jr Vancomycin pharmacokinetics in normal and morbidly obese subjects. Antimicrob Agents Chemother. 1982 Apr;21(4):575–580. doi: 10.1128/aac.21.4.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cynamon M. H., Granato P. A. Comparison of the in vitro activities of teichomycin A2 and vancomycin against staphylococci and enterococci. Antimicrob Agents Chemother. 1982 Mar;21(3):504–505. doi: 10.1128/aac.21.3.504. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Duchin K. L., Singhvi S. M., Willard D. A., Migdalof B. H., McKinstry D. N. Captopril kinetics. Clin Pharmacol Ther. 1982 Apr;31(4):452–458. doi: 10.1038/clpt.1982.59. [DOI] [PubMed] [Google Scholar]
  7. Fainstein V., LeBlanc B., Bodey G. P. Comparative in vitro study of teichomycin A2. Antimicrob Agents Chemother. 1983 Mar;23(3):497–499. doi: 10.1128/aac.23.3.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fietta A., Bersani C., Mangiarotti P., Gialdroni Grassi G. In vitro activity of teichomycin against isolates of gram-positive bacteria. Chemotherapy. 1983;29(4):275–282. doi: 10.1159/000238209. [DOI] [PubMed] [Google Scholar]
  9. Jadeja L., Fainstein V., LeBlanc B., Bodey G. P. Comparative in vitro activities of teichomycin and other antibiotics against JK diphtheroids. Antimicrob Agents Chemother. 1983 Aug;24(2):145–146. doi: 10.1128/aac.24.2.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Krogstad D. J., Moellering R. C., Jr, Greenblatt D. J. Single-dose kinetics of intravenous vancomycin. J Clin Pharmacol. 1980 Apr;20(4 Pt 1):197–201. doi: 10.1002/j.1552-4604.1980.tb01696.x. [DOI] [PubMed] [Google Scholar]
  11. Neu H. C., Labthavikul P. In vitro activity of teichomycin compared with those of other antibiotics. Antimicrob Agents Chemother. 1983 Sep;24(3):425–428. doi: 10.1128/aac.24.3.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Pallanza R., Berti M., Goldstein B. P., Mapelli E., Randisi E., Scotti R., Arioli V. Teichomycin: in-vitro and in-vivo evaluation in comparison with other antibiotics. J Antimicrob Chemother. 1983 May;11(5):419–425. doi: 10.1093/jac/11.5.419. [DOI] [PubMed] [Google Scholar]
  13. Parenti F., Beretta G., Berti M., Arioli V. Teichomycins, new antibiotics from Actinoplanes teichomyceticus Nov. Sp. I. Description of the producer strain, fermentation studies and biological properties. J Antibiot (Tokyo) 1978 Apr;31(4):276–283. doi: 10.7164/antibiotics.31.276. [DOI] [PubMed] [Google Scholar]
  14. Traina G. L., Bonati M. Pharmacokinetics of teicoplanin in man after intravenous administration. J Pharmacokinet Biopharm. 1984 Apr;12(2):119–128. doi: 10.1007/BF01059273. [DOI] [PubMed] [Google Scholar]
  15. Varaldo P. E., Debbia E., Schito G. C. In vitro activity of teichomycin and vancomycin alone and in combination with rifampin. Antimicrob Agents Chemother. 1983 Mar;23(3):402–406. doi: 10.1128/aac.23.3.402. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES