Abstract
The acyclic nucleoside DHPG [9-(1,3-dihydroxy-2-propoxymethyl)guanine] and recombinant human alpha-interferon of clones A/D potentiate each other's antiviral activity against a systemic infection with herpes simplex virus type 2. The effective dose at which 50% of the mice survived was lowered approximately 10-fold for DHPG when it was given in combination with a marginally effective dose of alpha-interferon and greater than 10-fold for alpha-interferon when it was given in combination with a nontherapeutic dose of DHPG.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Berenbaum M. C. A method for testing for synergy with any number of agents. J Infect Dis. 1978 Feb;137(2):122–130. doi: 10.1093/infdis/137.2.122. [DOI] [PubMed] [Google Scholar]
- Eppstein D. A., Marsh Y. V. Potent synergistic inhibition of herpes simplex virus-2 by 9-[(1, 3-dihydroxy-2-propoxy)methyl]guanine in combination with recombinant interferons. Biochem Biophys Res Commun. 1984 Apr 16;120(1):66–73. doi: 10.1016/0006-291x(84)91414-1. [DOI] [PubMed] [Google Scholar]
- Fraser-Smith E. B., Eppstein D. A., Marsh Y. V., Matthews T. R. Enhanced efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine in combination with beta-interferon against herpes simplex virus type 2 in mice. Antimicrob Agents Chemother. 1984 May;25(5):563–565. doi: 10.1128/aac.25.5.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Janz C., Wigand R. Combined interaction of antiherpes substances and interferon beta on the multiplication of herpes simplex virus. Arch Virol. 1982;73(2):135–143. doi: 10.1007/BF01314722. [DOI] [PubMed] [Google Scholar]
- Kramer M. J., Dennin R., Kramer C., Jones G., Connell E., Rolon N., Gruarin A., Kale R., Trown P. W. Cell and virus sensitivity studies with recombinant human alpha interferons. J Interferon Res. 1983;3(4):425–435. doi: 10.1089/jir.1983.3.425. [DOI] [PubMed] [Google Scholar]
- Lee S. H., Chiu H., Rinderknecht E., Sabo W., Stebbing N. Importance of treatment regimen of interferon as an antitumor agent. Cancer Res. 1983 Sep;43(9):4172–4175. [PubMed] [Google Scholar]
- Levin M. J., Leary P. L. Inhibition of human herpesviruses by combination of acyclovir and human leukocyte interferon. Infect Immun. 1981 Jun;32(3):995–999. doi: 10.1128/iai.32.3.995-999.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rehberg E., Kelder B., Hoal E. G., Pestka S. Specific molecular activities of recombinant and hybrid leukocyte interferons. J Biol Chem. 1982 Oct 10;257(19):11497–11502. [PubMed] [Google Scholar]
- Stanwick T. L., Schinazi R. F., Campbell D. E., Nahmias A. J. Combined antiviral effect of interferon and acyclovir on herpes simplex virus types 1 and 2. Antimicrob Agents Chemother. 1981 Apr;19(4):672–674. doi: 10.1128/aac.19.4.672. [DOI] [PMC free article] [PubMed] [Google Scholar]