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. 1985 Apr;27(4):625–631. doi: 10.1128/aac.27.4.625

Immunoadjuvant activity of amphotericin B as displayed in mice infected with Candida albicans.

F Bistoni, A Vecchiarelli, R Mazzolla, P Puccetti, P Marconi, E Garaci
PMCID: PMC180109  PMID: 3890731

Abstract

Mice receiving a single intraperitoneal injection of amphotericin B showed increased resistance to subsequent challenge with either Candida albicans or Staphylococcus aureus. This enhancement of resistance was obvious in terms of both survival criteria and clearance of the intravenously injected organism from different organs. The protective effect of amphotericin B was conditioned by dose, time of drug administration, and size of yeast or bacterial inoculum and was reversed by cyclophosphamide. Effector cells from mice treated with amphotericin B displayed enhanced fungicidal activity in vitro as measured in a short-term 51Cr release assay. Macrophages from intact animals exposed in vitro to amphotericin B also acquired strong candidacidal reactivity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkinson A. J., Jr, Bennett J. E. Amphotericin B pharmacokinetics in humans. Antimicrob Agents Chemother. 1978 Feb;13(2):271–276. doi: 10.1128/aac.13.2.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Baccarini M., Bistoni F., Puccetti P., Garaci E. Natural cell-mediated cytotoxicity against Candida albicans induced by cyclophosphamide: nature of the in vitro cytotoxic effector. Infect Immun. 1983 Oct;42(1):1–9. doi: 10.1128/iai.42.1.1-9.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Baccarini M., Blasi E., Puccetti P., Bistoni F. Phagocytic killing of Candida albicans by different murine effector cells. Sabouraudia. 1983 Dec;21(4):271–286. [PubMed] [Google Scholar]
  4. Bistoni F., Baccarini M., Blasi E., Marconi P., Puccetti P., Garaci E. Correlation between in vivo and in vitro studies of modulation of resistance to experimental Candida albicans infection by cyclophosphamide in mice. Infect Immun. 1983 Apr;40(1):46–55. doi: 10.1128/iai.40.1.46-55.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bistoni F., Baccarini M., Blasi E., Puccetti P., Marconi P. A radiolabel release microassay for phagocytic killing of Candida albicans. J Immunol Methods. 1982 Aug 13;52(3):369–377. doi: 10.1016/0022-1759(82)90008-4. [DOI] [PubMed] [Google Scholar]
  6. Blanke T. J., Little J. R., Shirley S. F., Lynch R. G. Augmentation of murine immune responses by amphotericin B. Cell Immunol. 1977 Sep;33(1):180–190. doi: 10.1016/0008-8749(77)90145-9. [DOI] [PubMed] [Google Scholar]
  7. Canales L., Middlemas R. O., 3rd, Louro J. M., South M. A. Immunological observations in chronic mucocutaneous candidiasis. Lancet. 1969 Sep 13;2(7620):567–571. doi: 10.1016/s0140-6736(69)90264-5. [DOI] [PubMed] [Google Scholar]
  8. Chapman H. A., Jr, Hibbs J. B., Jr Modulation of macrophage tumoricidal capability by polyene antibiotics: support for membrane lipid as a regulatory determinant of macrophage function. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4349–4353. doi: 10.1073/pnas.75.9.4349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cox R. A., Vivas J. R. Spectrum of in vivo and in vitro cell-mediated immune responses in coccidioidomycosis. Cell Immunol. 1977 Jun 1;31(1):130–141. doi: 10.1016/0008-8749(77)90012-0. [DOI] [PubMed] [Google Scholar]
  10. Craven P. C., Ludden T. M., Drutz D. J., Rogers W., Haegele K. A., Skrdlant H. B. Excretion pathways of amphotericin B. J Infect Dis. 1979 Sep;140(3):329–341. doi: 10.1093/infdis/140.3.329. [DOI] [PubMed] [Google Scholar]
  11. Lin S. H., Medoff G., Kobayashi G. S. Effects of amphotericin B on macrophages and their precursor cells. Antimicrob Agents Chemother. 1977 Jan;11(1):154–160. doi: 10.1128/aac.11.1.154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Marconi P., Bistoni F., Boncio L., Bersiani A., Bravi P., Pitzurra M. Utilizzazione di soluzione salina ipertonica di cloruro di potassio (3M KC1) per l'estrazione di antigeni solubili da Candia albicans. Ann Sclavo. 1976 Jan-Feb;18(1):61–66. [PubMed] [Google Scholar]
  13. Medoff G., Valeriote F., Ryan J., Tolen S. Response of transplanted AKR leukemia to combination therapy with amphotericin B and 1,3-bis(2-chloroethyl)-1-nitrosourea: dose and schedule dependency. J Natl Cancer Inst. 1977 Apr;58(4):949–953. doi: 10.1093/jnci/58.4.949. [DOI] [PubMed] [Google Scholar]
  14. Newberry W. M., Jr, Chandler J. W., Jr, Chin T. D., Kirkpatrick C. H. Immunology of the mycoses. I. Depressed lymphocyte transformation in chronic histoplasmosis. J Immunol. 1968 Feb;100(2):436–443. [PubMed] [Google Scholar]
  15. Olds G. R., Stewart S. J., Ellner J. J. Amphotericin B-induced resistance to Schistosoma mansoni. J Immunol. 1981 May;126(5):1667–1670. [PubMed] [Google Scholar]
  16. Paterson P. Y., Semo R., Blumenschein G., Swelstad J. Mucocutaneous candidiasis, anergy and a plasma inhibitor of cellular immunity: reversal after amphotericin B therapy. Clin Exp Immunol. 1971 Nov;9(5):595–602. [PMC free article] [PubMed] [Google Scholar]
  17. Shirley S. F., Little J. R. Immunopotentiating effects of amphotericin B. I. Enhanced contact sensitivity in mice. J Immunol. 1979 Dec;123(6):2878–2882. [PubMed] [Google Scholar]
  18. Thomas M. Z., Medoff G., Kobayashi G. S. Changes in murine resistance to Listeria monocytogenes infection induced by amphotericin B. J Infect Dis. 1973 Apr;127(4):373–377. doi: 10.1093/infdis/127.4.373. [DOI] [PubMed] [Google Scholar]

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