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. 1995 Sep;57(3):636–643.

Linkage Analyses of Chromosome 18 Markers Do Not Identify a Major Susceptibility Locus for Bipolar Affective Disorder in the Old Order Amish

David L Pauls, Jurg Ott, Steven M Paul, Cleona R Allen, Cathy S J Fann, John P Carulli, Kathleen M Falls, Christine A Bouthillier, Thomas C Gravius, Tim P Keith, Janice A Egeland, Edward I Ginns
PMCID: PMC1801276  PMID: 7668292

Abstract

Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar I (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP I individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population.

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Selected References

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