Abstract
The pharmacokinetics of cefazolin in patients undergoing orthopedic surgery with either general (enflurane) or local (lidocaine or marcaine) anesthesia were studied. No differences in either mean serum levels at 30, 60, or 120 min after the intravenous injection of cefazolin or serum half-lives were seen between the two groups of patients.
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Selected References
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- Cunha B. A., Gossling H. R., Pasternak H. S., Nightingale C. H., Quintiliani R. Penetration of cephalosporins into bone. Infection. 1984 Mar-Apr;12(2):80–84. doi: 10.1007/BF01641676. [DOI] [PubMed] [Google Scholar]
- Cunha B. A., Gossling H. R., Pasternak H. S., Nightingale C. H., Quintiliani R. The penetration characteristics of cefazolin, cephalothin, and cephradine into bone in patients undergoing total hip replacement. J Bone Joint Surg Am. 1977 Oct;59(7):856–859. [PubMed] [Google Scholar]
- Nicholas P., Meyers B. R., Hirschman S. Z. Pharmacology of cefazolin in human volunteers. J Clin Pharmacol. 1973 Aug-Sep;13(8):325–331. doi: 10.1002/j.1552-4604.1973.tb00219.x. [DOI] [PubMed] [Google Scholar]
- Nightingale C. H., Bassaris H., Tilton R., Quintiliani R. Changes in pharmacokinetics of cefazolin due to stress. J Pharm Sci. 1975 Apr;64(4):712–714. doi: 10.1002/jps.2600640437. [DOI] [PubMed] [Google Scholar]
- Rattie E. S., Ravin L. J. Pharmacokinetic interpretation of blood levels and urinary excretion data for cefazolin and cephalothin after intravenous and intramuscular administration in humans. Antimicrob Agents Chemother. 1975 May;7(5):606–613. doi: 10.1128/aac.7.5.606. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reller L. B., Karney W. W., Beaty H. N., Holmes K. K., Turck M. Evaluation of cefazolin, a new cephalosporin antibiotic. Antimicrob Agents Chemother. 1973 Apr;3(4):488–497. doi: 10.1128/aac.3.4.488. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scheld W. M., Spyker D. A., Donowitz G. R., Bolton W. K., Sande M. A. Moxalactam and cefazolin: comparative pharmacokinetics in normal subjects. Antimicrob Agents Chemother. 1981 Apr;19(4):613–619. doi: 10.1128/aac.19.4.613. [DOI] [PMC free article] [PubMed] [Google Scholar]