Abstract
Fifteen male patients with prolactin-secreting pituitary adenomas were studied before and after transsphenoidal microsurgical treatment. Loss of libido and sexual impotence were the most frequent symptoms, being present in 12. Visual defects were present in seven patients, gynecomastia was observed in four and galactorrhea was noted in three. Most of the tumours were large; only one was a microadenoma. Four patients were cured by the operation. In all the other patients the plasma levels of prolactin were significantly lowered and the visual defects corrected or lessened, but sexual impotence was not modified. No important deficiency of the pituitary gland was induced by the operation. The results indicate that in males loss of libido and sexual impotence are frequent and early manifestations of prolactinomas, and that transsphenoidal resection is a safe therapeutic approach.
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Selected References
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- Boden G., Soeldner J. S. A sensitive double antibody radioimmunoassay for human growth hormone (HGH): levels of serum HGH following rapid tolbutamide infusion. Diabetologia. 1967 Oct;3(5):413–421. doi: 10.1007/BF01228076. [DOI] [PubMed] [Google Scholar]
- Boyar R. M., Kapen S., Finkelstein J. W., Perlow M., Sassin J. F., Fukushima D. K., Weitzman E. D., Hellman L. Hypothalamic-pituitary function in diverse hyperprolactinemic states. J Clin Invest. 1974 Jun;53(6):1588–1598. doi: 10.1172/JCI107709. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carter J. N., Tyson J. E., Tolis G., Van Vliet S., Faiman C., Friesen H. G. Prolactin-screening tumors and hypogonadism in 22 men. N Engl J Med. 1978 Oct 19;299(16):847–852. doi: 10.1056/NEJM197810192991602. [DOI] [PubMed] [Google Scholar]
- Fossati P., Strauch G., Tourniaire J. Etude de l'activité de la bromocriptine dans les états d'hyperprolactinémie. Résultats d'un essai coopératif chez 135 patients. Nouv Presse Med. 1976 Jul 3;5(27):1687–1691. [PubMed] [Google Scholar]
- Franks S., Nabarro J. D. Prevalence and presentation of hyperprolactinaemia in patients with "functionless" pituitary tumours. Lancet. 1977 Apr 9;1(8015):778–780. doi: 10.1016/s0140-6736(77)92959-2. [DOI] [PubMed] [Google Scholar]
- Hardy J., Vezina J. L. Transsphenoidal neurosurgery of intracranial neoplasm. Adv Neurol. 1976;15:261–273. [PubMed] [Google Scholar]
- Hardy J., Wigser S. M. Trans-sphenoidal surgery of pituitary fossa tumors with televised radiofluoroscopic control. J Neurosurg. 1965 Dec;23(6):612–619. doi: 10.3171/jns.1965.23.6.0612. [DOI] [PubMed] [Google Scholar]
- Hwang P., Guyda H., Friesen H. A radioimmunoassay for human prolactin. Proc Natl Acad Sci U S A. 1971 Aug;68(8):1902–1906. doi: 10.1073/pnas.68.8.1902. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jaquet P., Grisoli F., Guibout M., Lissitzky J. C., Carayon P. Prolactin secreting tumors. Endocrine status before and after surgery in 33 women. J Clin Endocrinol Metab. 1978 Mar;46(3):459–466. doi: 10.1210/jcem-46-3-459. [DOI] [PubMed] [Google Scholar]
- Magrini B., Ebiner J. R., Burckhardt P., Felber J. P. Study on the relationship between plasma prolactin levels and androgen metabolism in man. J Clin Endocrinol Metab. 1976 Oct;43(4):944–947. doi: 10.1210/jcem-43-4-944. [DOI] [PubMed] [Google Scholar]
- McNatty K. P., Sawers R. S., McNeilly A. S. A possible role for prolactin in control of steroid secretion by the human Graafian follicle. Nature. 1974 Aug 23;250(5468):653–655. doi: 10.1038/250653a0. [DOI] [PubMed] [Google Scholar]
- Midgley A. R. Radioimmunoassay for human follicle-stimulating hormone. J Clin Endocrinol Metab. 1967 Feb;27(2):295–299. doi: 10.1210/jcem-27-2-295. [DOI] [PubMed] [Google Scholar]
- Nagulesparen M., Ang V., Jenkins J. S. Bromocriptine treatment of males with pituitary tumours, hyperprolactinaemia, and hypogonadism. Clin Endocrinol (Oxf) 1978 Jul;9(1):73–79. doi: 10.1111/j.1365-2265.1978.tb03574.x. [DOI] [PubMed] [Google Scholar]
- Odell W. D., Ross G. T., Rayford P. L. Radioimmunoassay for human luteinizing hormone. Metabolism. 1966 Apr;15(4):287–289. doi: 10.1016/0026-0495(66)90142-9. [DOI] [PubMed] [Google Scholar]
- Robert F., Hardy J. Prolactin-secreting adenomas. A light and electron microscopical study. Arch Pathol. 1975 Dec;99(12):625–633. [PubMed] [Google Scholar]
- Segal S., Polishuk W. Z., Ben-David M. Hyperprolactinemic male infertility. Fertil Steril. 1976 Dec;27(12):1425–1427. doi: 10.1016/s0015-0282(16)42259-4. [DOI] [PubMed] [Google Scholar]
- Sheth A. R., Joshi L. R., Moodbidri S. B., Rao S. S. Serum prolactin levels in fertile and infertile men. Andrologie. 1973;5(4):297–298. doi: 10.1111/j.1439-0272.1973.tb00493.x. [DOI] [PubMed] [Google Scholar]
- Woolf P. D., Lee L. A., Leebaw W. F. Hypoglycemia as a provocative test of prolactin release. Metabolism. 1978 Jul;27(7):869–877. doi: 10.1016/0026-0495(78)90221-4. [DOI] [PubMed] [Google Scholar]
