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. 1985 Sep;28(3):375–377. doi: 10.1128/aac.28.3.375

Activity of selenazofurin against influenza A and B viruses in vitro.

R W Sidwell, J H Huffman, E W Call, H Alaghamandan, P D Cook, R K Robins
PMCID: PMC180256  PMID: 4073860

Abstract

Activity of the new antiviral compound selenazofurin was compared with the known active compounds ribavirin and amantadine against influenza A and B viruses. In experiments with Madin Darby canine kidney cells, selenazofurin inhibited the cytopathic effect and yield of influenza A/NWS/33 virus, with 50% effective dose ranges of 0.7 to 1.4 micrograms/ml (virus rating [VR], 1.3 to 1.4). The 50% effective dose range for ribavirin was 1.2 to 1.6 micrograms/ml (VR, 1.0 to 1.3), and for amantadine it was 9 micrograms/ml (VR, 0.9). Selenazofurin and ribavirin were similarly inhibitory to influenza B/Lee/40 virus, whereas amantadine was inactive. Selenazofurin appeared somewhat cytotoxic in these studies at concentrations as low as 1 micrograms/ml.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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