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. 1985 Sep;28(3):449–451. doi: 10.1128/aac.28.3.449

Synergistic effect of human leukocyte interferon and nonoxynol 9 against herpes simplex virus type 2.

F Rapp, H Wrzos
PMCID: PMC180273  PMID: 3000288

Abstract

The nonionic surfactant nonoxynol 9 (NP9), in combination with human alpha interferon, synergistically reduced the titer of herpes simplex virus type 2 (HSV-2) in vitro. The degree of synergy was highest at an interferon concentration of 10(3) IU/ml and an NP9 dilution of 1:1,500. We postulate that NP9 inactivates extracellular HSV-2, whereas interferon inhibits HSV-2 replication at the intracellular level.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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