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. 1985 Oct;28(4):561–564. doi: 10.1128/aac.28.4.561

Comparative evaluation of the 2-methyl-5-nitroimidazole compounds dimetridazole, metronidazole, secnidazole, ornidazole, tinidazole, carnidazole, and panidazole against Bacteroides fragilis and other bacteria of the Bacteroides fragilis group.

L Jokipii, A M Jokipii
PMCID: PMC180305  PMID: 4073879

Abstract

Tube-dilution MICs of seven 2-methyl-5-nitroimidazole compounds varying at the 1-substitution were determined against Bacteroides fragilis. Activities on a molar basis were ranked: tinidazole greater than panidazole greater than ornidazole greater than metronidazole greater than or equal to secnidazole greater than carnidazole greater than dimetridazole. Geometric mean MICs varied from 0.5 to 6.6 microM, and MICs against individual strains varied up to 50-fold between compounds. In general, the MIC of each drug correlated with that of each of the other drugs, but with tinidazole the correlation coefficients tended to be small and were not significant versus metronidazole and secnidazole. MICs against 14 other bacteria of the B. fragilis group, including B. distasonis, B. ovatus, B. thetaiotaomicron, B. uniformis, and B. vulgatus, were within the range determined for B. fragilis.

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Selected References

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  1. Cantelli-Forti G., Aicardi G., Guerra M. C., Barbaro A. M., Biagi G. L. Mutagenicity of a series of 25 nitroimidazoles and two nitrothiazoles in Salmonella typhimurium. Teratog Carcinog Mutagen. 1983;3(1):51–63. doi: 10.1002/1520-6866(1990)3:1<51::aid-tcm1770030107>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  2. Dornbusch K., Nord C. E. In vitro effect of metronidazole and tinidazole on anaerobic bacteria. Med Microbiol Immunol. 1974;160(4):265–267. doi: 10.1007/BF02121441. [DOI] [PubMed] [Google Scholar]
  3. Ferguson I. R., Smith L. L. Bacteroides fragilis and nitroimidazoles. J Antimicrob Chemother. 1976 Jun;2(2):220–221. doi: 10.1093/jac/2.2.220. [DOI] [PubMed] [Google Scholar]
  4. Füzi M., Csukás Z. A szájflóra mikroorganizmusainak metronidazol érzékenysége. Orv Hetil. 1969 Sep 14;110(37):2154–2155. [PubMed] [Google Scholar]
  5. Füzi M., Csukás Z. Veillonella-törzsek metronidazol-érzékenysége. Fogorv Sz. 1969 Nov;62(11):324–326. [PubMed] [Google Scholar]
  6. Gallusser A. Etude comparative, par trois méthodes, de la sensibilité au métronidazole et à l'ornidazole de bactéries anaérobies ou apparentées. Ann Microbiol (Paris) 1983 Sep-Oct;134B(2):307–321. [PubMed] [Google Scholar]
  7. Goldstein E. J., Sutter V. L., Finegold S. M. Comparative susceptibilities of anaerobic bacteria to metronidazole, ornidazole, and SC-28538. Antimicrob Agents Chemother. 1978 Oct;14(4):609–613. doi: 10.1128/aac.14.4.609. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jokipii A. M., Jokipii L. Bactericidal activity of tinidazole. An in vitro comparison of the effects of tinidazole and metronidazole against Bacteroides fragilis and other Anaerobic bacteria. Chemotherapy. 1977;23(1):25–31. doi: 10.1159/000221967. [DOI] [PubMed] [Google Scholar]
  9. Jokipii A. M., Jokipii L. Cerebrospinal fluid concentrations of metronidazole, tinidazole and ornidazole in rabbits. Infection. 1980;8(3):101–103. doi: 10.1007/BF01641471. [DOI] [PubMed] [Google Scholar]
  10. Jokipii A. M., Myllylä V. V., Hokkanen E., Jokipii L. Penetration of the blood brain barrier by metronidazole and tinidazole. J Antimicrob Chemother. 1977 May;3(3):239–245. doi: 10.1093/jac/3.3.239. [DOI] [PubMed] [Google Scholar]
  11. Jokipii L., Jokipii A. M. Bactericidal activity of metronidazole, tinidazole and ornidazole against Bacteroides fragilis in vitro. J Antimicrob Chemother. 1977 Nov;3(6):571–577. doi: 10.1093/jac/3.6.571. [DOI] [PubMed] [Google Scholar]
  12. Jokipii L., Jokipii A. M. In vitro susceptibility of Giardia lamblia trophozoites to metronidazole and tinidazole. J Infect Dis. 1980 Mar;141(3):317–325. doi: 10.1093/infdis/141.3.317. [DOI] [PubMed] [Google Scholar]
  13. Jokipii L., Jokipii A. M. Single-dose metronidazole and tinidazole as therapy for giardiasis: success rates, side effects, and drug absorption and elimination. J Infect Dis. 1979 Dec;140(6):984–988. doi: 10.1093/infdis/140.6.984. [DOI] [PubMed] [Google Scholar]
  14. Jokipii L., Jokipii A. M. Treatment of giardiasis: comparative evaluation of ornidazole and tinidazole as a single oral dose. Gastroenterology. 1982 Aug;83(2):399–404. [PubMed] [Google Scholar]
  15. Knox R. J., Knight R. C., Edwards D. I. Interaction of nitroimidazole drugs with DNA in vitro: structure-activity relationships. Br J Cancer. 1981 Nov;44(5):741–745. doi: 10.1038/bjc.1981.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lindmark D. G., Müller M. Antitrichomonad action, mutagenicity, and reduction of metronidazole and other nitroimidazoles. Antimicrob Agents Chemother. 1976 Sep;10(3):476–482. doi: 10.1128/aac.10.3.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Prince H. N., Grunberg E., Titsworth E., DeLorenzo W. F. Effects of l-(2-nitro-l-imidazolyl)-3-methoxy-2-propanol and 2-methyl-5-nitroimidazole-l-ethanol against anaerobic and aerobic bacteria and protozoa. Appl Microbiol. 1969 Nov;18(5):728–730. doi: 10.1128/am.18.5.728-730.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Reynolds A. V., Hamilton-Miller J. M., Brumfitt W. A comparison of the in vitro activity of metronidazole, tinidazole, and nimorazole against Gram-negative anaerobic bacilli. J Clin Pathol. 1975 Oct;28(10):775–778. doi: 10.1136/jcp.28.10.775. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Reynolds A. V. The activity of nitro-compounds against Bacteroides fragilis is related to their electron affinity. J Antimicrob Chemother. 1981 Aug;8(2):91–99. doi: 10.1093/jac/8.2.91. [DOI] [PubMed] [Google Scholar]
  20. Symonds J. Secnidazole--a nitroimidazole with a prolonged serum half-life. J Antimicrob Chemother. 1979 Jul;5(4):484–486. doi: 10.1093/jac/5.4.484. [DOI] [PubMed] [Google Scholar]
  21. Videau D., Niel G., Siboulet A., Catalan F. Secnidazole. A 5-nitroimidazole derivative with a long half-life. Br J Vener Dis. 1978 Apr;54(2):77–80. doi: 10.1136/sti.54.2.77. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Viitanen J., Auvinen O., Tunturi T., Männistö P., Haataja H. Concentrations of metronidazole and tinidazole in abdominal tissues after a single intravenous infusion and repetitive oral administration. Chemotherapy. 1984;30(4):211–215. doi: 10.1159/000238270. [DOI] [PubMed] [Google Scholar]
  23. Voogd C. E. On the mutagenicity of nitroimidazoles. Mutat Res. 1981 May;86(3):243–277. doi: 10.1016/0165-1110(81)90006-3. [DOI] [PubMed] [Google Scholar]
  24. Voogd C. E., Van der Stel J. J., Jacobs J. J. The mutagenic action of nitroimidazoles. II. Tinidazole, ipronidazole, panidazole and ornidazole. Mutat Res. 1977 Apr;48(2):155–161. doi: 10.1016/0027-5107(77)90155-5. [DOI] [PubMed] [Google Scholar]
  25. Voogd C. E., van der Stel J. J., Jacobs J. J. The mutagenic action of nitroimidazoles. IV. A comparison of the mutagenic action of several nitroimidazoles and some imidazoles. Mutat Res. 1979 Mar;66(3):207–221. doi: 10.1016/0165-1218(79)90082-x. [DOI] [PubMed] [Google Scholar]
  26. Wise R., Andrews J. M., Bedford K. A. The activity of four antimicrobial agents. Including three nitroimidazole compounds, against Bacteroides sp. Chemotherapy. 1977;23(1):19–24. doi: 10.1159/000221966. [DOI] [PubMed] [Google Scholar]
  27. Wust J. Susceptibility of anaerobic bacteria to metronidazole, ornidazole, and tinidazole and routine susceptibility testing by standardized methods. Antimicrob Agents Chemother. 1977 Apr;11(4):631–637. doi: 10.1128/aac.11.4.631. [DOI] [PMC free article] [PubMed] [Google Scholar]

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