Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1985 Dec;28(6):778–780. doi: 10.1128/aac.28.6.778

Decreased biliary excretion of piperacillin after percutaneous relief of extrahepatic obstructive jaundice.

J I Blenkharn, N Habib, D Mok, L John, G A McPherson, R N Gibson, L H Blumgart, I S Benjamin
PMCID: PMC180327  PMID: 4083861

Abstract

The biliary excretion of piperacillin has been assessed in 11 patients with obstructive jaundice due to hilar cholangiocarcinoma. After a 1-g intravenous dose administered 30 min before preliminary percutaneous transhepatic cholangiography, no drug was detected in the bile of seven patients; in four others, drug concentrations were far below the corresponding level in serum. After a period of external biliary drainage of up to 28 days, levels of antibiotic in bile after intravenous administration were only minimally increased. The results suggest that although the impairment of hepatic function may be improved by external biliary decompression when assessed by a fall in plasma bilirubin, the biliary elimination of piperacillin and related beta-lactam antibiotics may remain impaired for prolonged periods.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blenkharn J. I., Blumgart L. H. Streptococcal bacteremia in hepatobiliary operations. Surg Gynecol Obstet. 1985 Feb;160(2):139–141. [PubMed] [Google Scholar]
  2. Blenkharn J. I., McPherson G. A., Blumgart L. H. Septic complications of percutaneous transhepatic biliary drainage. Evaluation of a new closed drainage system. Am J Surg. 1984 Mar;147(3):318–321. doi: 10.1016/0002-9610(84)90158-2. [DOI] [PubMed] [Google Scholar]
  3. Dooley J. S., Gooding A., Hamilton-Miller J. M., Brumfitt W., Sherlock S. The biliary excretion and pharmacokinetics of mezlocillin in jaundiced patients with external bile drainage. Liver. 1983 Aug;3(4):201–206. doi: 10.1111/j.1600-0676.1983.tb00868.x. [DOI] [PubMed] [Google Scholar]
  4. Keighley M. R., Drysdale R. B., Quoraishi A. H., Burdon D. W., Alexander-Willians J. Antibiotics in biliary disease: the relative importance of antibiotic concentrations in the bile and serum. Gut. 1976 Jul;17(7):495–500. doi: 10.1136/gut.17.7.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Koyama K., Takagi Y., Ito K., Sato T. Experimental and clinical studies on the effect of biliary drainage in obstructive jaundice. Am J Surg. 1981 Aug;142(2):293–299. doi: 10.1016/0002-9610(81)90296-8. [DOI] [PubMed] [Google Scholar]
  6. Levi J. U., Martinez O. V., Malinin T. I., Zeppa R., Livingstone A., Hutson D., Calhoun P. Decreased biliary excretion of cefamandole after percutaneous biliary decompression in patients with total common bile duct obstruction. Antimicrob Agents Chemother. 1984 Dec;26(6):944–946. doi: 10.1128/aac.26.6.944. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Martinez O. V., Levi J. U., Devlin R. G. Biliary excretion of aztreonam in patients with biliary tract disease. Antimicrob Agents Chemother. 1984 Mar;25(3):358–361. doi: 10.1128/aac.25.3.358. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McPherson G. A., Benjamin I. S., Habib N. A., Bowley N. B., Blumgart L. H. Percutaneous transhepatic drainage in obstructive jaundice: advantages and problems. Br J Surg. 1982 May;69(5):261–264. doi: 10.1002/bjs.1800690511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McPherson G. A., Benjamin I. S., Hodgson H. J., Bowley N. B., Allison D. J., Blumgart L. H. Pre-operative percutaneous transhepatic biliary drainage: the results of a controlled trial. Br J Surg. 1984 May;71(5):371–375. doi: 10.1002/bjs.1800710522. [DOI] [PubMed] [Google Scholar]
  10. Nagar H., Berger S. A. The excretion of antibiotics by the biliary tract. Surg Gynecol Obstet. 1984 Jun;158(6):601–607. [PubMed] [Google Scholar]
  11. Quintiliani R., French M., Nightingale C. H. First and second generation cephalosporins. Med Clin North Am. 1982 Jan;66(1):183–197. doi: 10.1016/s0025-7125(16)31452-3. [DOI] [PubMed] [Google Scholar]
  12. Strachan C. J. Antibiotics for biliary infections. Scott Med J. 1978 Jul;23(3):241–244. doi: 10.1177/003693307802300311. [DOI] [PubMed] [Google Scholar]
  13. Taylor E. W., Poxon V., Alexander-Williams J., Jackson D. Biliary excretion of piperacillin. J Int Med Res. 1983;11(1):28–31. doi: 10.1177/030006058301100106. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES