Abstract
Sultamicillin, an antibiotic combining ampicillin and the beta-lactamase inhibitor sulbactam, was administered to 13 patients diagnosed as having acute sinusitis. Specimens from sinus were obtained for all 13 patients by transantral puncture. Pharmacokinetics, bacteriology, and therapeutic efficacy were assessed. Eighty-five percent (11 of 13) were cured; two treatment failures were subsequently shown to have chronic (rather than acute) sinusitis during surgical exploration. Diarrhea was frequently encountered, and Clostridium difficile-associated enteritis was documented for one patient. Beta-lactamase-producing organisms were not encountered in this study; however, this study provides impetus for further controlled clinical trials.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aswapokee N., Neu H. C. A sulfone beta-lactam compound which acts as a beta-lactamase inhibitor. J Antibiot (Tokyo) 1978 Dec;31(12):1238–1244. doi: 10.7164/antibiotics.31.1238. [DOI] [PubMed] [Google Scholar]
- English A. R., Retsema J. A., Girard A. E., Lynch J. E., Barth W. E. CP-45,899, a beta-lactamase inhibitor that extends the antibacterial spectrum of beta-lactams: initial bacteriological characterization. Antimicrob Agents Chemother. 1978 Sep;14(3):414–419. doi: 10.1128/aac.14.3.414. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fu K. P., Neu H. C. Comparative inhibition beta-lactamases by novel beta-lactam compounds. Antimicrob Agents Chemother. 1979 Feb;15(2):171–176. doi: 10.1128/aac.15.2.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jannert M., Andréasson L., Helin I., Pettersson H. Acute sinusitis in children--symptoms, clinical findings and bacteriology related to initial radiologic appearance. Int J Pediatr Otorhinolaryngol. 1982 Jun;4(2):139–148. doi: 10.1016/0165-5876(82)90089-1. [DOI] [PubMed] [Google Scholar]
- Plouffe J. F. Treatment of infections caused by ampicillin-resistant pathogens with a combination of ampicillin and CP-45,899. Antimicrob Agents Chemother. 1982 Mar;21(3):519–520. doi: 10.1128/aac.21.3.519. [DOI] [PMC free article] [PubMed] [Google Scholar]