Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1986 Jan;29(1):104–106. doi: 10.1128/aac.29.1.104

Synergistic effects of dicloxacillin or clavulanic acid in combination with penicillin G or cephalothin against Yersinia enterocolitica.

M Jimenez-Valera, A Ruiz-Bravo, A Ramos-Cormenzana
PMCID: PMC180372  PMID: 3488014

Abstract

Cultures of Yersinia enterocolitica grown at 22 degrees C produced beta-lactamases, whereas cultures grown at 37 degrees C produced these enzymes much less effectively. Both dicloxacillin and clavulanic acid inhibited the beta-lactamase activity of bacterial crude extracts and potentiated the activity of penicillin G or cephalothin against 14 Y. enterocolitica strains. It appeared that the beta-lactamase activity present in Y. enterocolitica cells grown at 37 degrees C was great enough to play a role in bacterial resistance to beta-lactam antibiotics, since combining penicillin G or cephalothin with clavulanic acid or dicloxacillin resulted in synergistic activity against cultures grown at 37 degrees C that was equal to or greater than the activity against cultures grown at 22 degrees C.

Full text

PDF
104

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bottone E. J. Yersinia enterocolitica: a panoramic view of a charismatic microorganism. CRC Crit Rev Microbiol. 1977;5(2):211–241. doi: 10.3109/10408417709102312. [DOI] [PubMed] [Google Scholar]
  2. Cornelis G., Abraham E. P. Beta-lactamases from Yersinia enterocolitica. J Gen Microbiol. 1975 Apr;87(2):273–284. doi: 10.1099/00221287-87-2-273. [DOI] [PubMed] [Google Scholar]
  3. Cornelis G. Distribution of beta-lactamases A and B in some groups of Yersinia enterocolitica and their role in resistance. J Gen Microbiol. 1975 Dec;91(2):391–402. doi: 10.1099/00221287-91-2-391. [DOI] [PubMed] [Google Scholar]
  4. Hallander H. O., Dornbusch K., Gezelius L., Jacobson K., Karlsson I. Synergism between aminoglycosides and cephalosporins with antipseudomonal activity: interaction index and killing curve method. Antimicrob Agents Chemother. 1982 Nov;22(5):743–752. doi: 10.1128/aac.22.5.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hamilton-Miller J. M. Inhibition of beta-lactamase: a continuing story. J Antimicrob Chemother. 1977 May;3(3):195–196. doi: 10.1093/jac/3.3.195. [DOI] [PubMed] [Google Scholar]
  6. Kammer R. B., Preston D. A., Turner J. R., Hawley L. C. Rapid detection of ampicillin-resistant Haemophilus influenzae and their susceptibility to sixteen antibiotics. Antimicrob Agents Chemother. 1975 Jul;8(1):91–94. doi: 10.1128/aac.8.1.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Maddocks J. L., May J. R. "Indirect pathogenicity" of penicillinase-producing enterobacteria in chronic bronchial infections. Lancet. 1969 Apr 19;1(7599):793–795. doi: 10.1016/s0140-6736(69)92063-7. [DOI] [PubMed] [Google Scholar]
  8. Miller J. M., Baker C. N., Thornsberry C. Inhibition of beta-lactamase in Neisseria gonorrhoeae by sodium clavulanate. Antimicrob Agents Chemother. 1978 Nov;14(5):794–796. doi: 10.1128/aac.14.5.794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ogawara H. Antibiotic resistance in pathogenic and producing bacteria, with special reference to beta-lactam antibiotics. Microbiol Rev. 1981 Dec;45(4):591–619. doi: 10.1128/mr.45.4.591-619.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Paisley J. W., Washington J. A., 2nd Combined activitiy of clavulanic acid and ticarcillin against ticarcillin-resistant, gram-negative bacilli. Antimicrob Agents Chemother. 1978 Aug;14(2):224–227. doi: 10.1128/aac.14.2.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Reading C., Cole M. Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother. 1977 May;11(5):852–857. doi: 10.1128/aac.11.5.852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Renzini G., Ravagnan G., Oliva B. The microbiological properties of a dicloxacillin-hetacillin combination. Chemotherapy. 1973;19(6):367–378. doi: 10.1159/000221477. [DOI] [PubMed] [Google Scholar]
  13. Sargent M. G. Rapid fixed-time assay for penicillinase. J Bacteriol. 1968 Apr;95(4):1493–1494. doi: 10.1128/jb.95.4.1493-1494.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sawai T., Takahashi I., Yamagishi S. Iodometric assay method for beta-lactamase with various beta-lactam antibiotics as substrates. Antimicrob Agents Chemother. 1978 Jun;13(6):910–913. doi: 10.1128/aac.13.6.910. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES