Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1986 Jan;29(1):168–170. doi: 10.1128/aac.29.1.168

Effect of low-dose dopamine on the pharmacokinetics of tobramycin in dogs.

M G Kirby, J F Dasta, D K Armstrong, R Tallman Jr
PMCID: PMC180388  PMID: 3729328

Abstract

Low-dose dopamine or a placebo was given to six healthy mongrel dogs, each receiving tobramycin at 2.0 mg/kg on consecutive days in a randomized crossover fashion. Dopamine increased the total and renal clearances and elimination rate constant of tobramycin by 12.5, 20, and 25.9%, respectively, suggesting that low-dose dopamine increases the clearance of tobramycin in dogs primarily through renal mechanisms.

Full text

PDF
168

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adelman M. H., Harrison N. J., Wels P. B., Schentag J. J. Renal handling of gentamicin by normal and ischemic canine kidneys. J Lab Clin Med. 1982 Aug;100(2):201–210. [PubMed] [Google Scholar]
  2. Andrews J. M., Wise R. A comparison of the homogeneous enzyme immunoassay and polarization fluoroimmunoassay of gentamicin. J Antimicrob Chemother. 1984 Nov;14(5):509–520. doi: 10.1093/jac/14.5.509. [DOI] [PubMed] [Google Scholar]
  3. Chiu P. J., Brown A., Miller G., Long J. F. Renal extraction of gentamicin in anesthetized dogs. Antimicrob Agents Chemother. 1976 Aug;10(2):277–282. doi: 10.1128/aac.10.2.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Contrepois A., Brion N., Garaud J. J., Faurisson F., Delatour F., Levy J. C., Deybach J. C., Carbon C. Renal disposition of gentamicin, dibekacin, tobramycin, netilmicin, and amikacin in humans. Antimicrob Agents Chemother. 1985 Apr;27(4):520–524. doi: 10.1128/aac.27.4.520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Garrett E. R. Pharmacokinetics and clearances related to renal processes. Int J Clin Pharmacol Biopharm. 1978 Apr;16(4):155–172. [PubMed] [Google Scholar]
  6. Gifford R. R., Brock H. T., Dayton P. G., Goldberg L. I. Increased clearances of phenobarbital and salicylate produced by dopamine in the dog. Am J Med Sci. 1969 Nov;258(5):351–358. doi: 10.1097/00000441-196911000-00006. [DOI] [PubMed] [Google Scholar]
  7. Goldberg L. I. Cardiovascular and renal actions of dopamine: potential clinical applications. Pharmacol Rev. 1972 Mar;24(1):1–29. [PubMed] [Google Scholar]
  8. Goldberg L. I. Dopamine--clinical uses of an endogenous catecholamine. N Engl J Med. 1974 Oct 3;291(14):707–710. doi: 10.1056/NEJM197410032911405. [DOI] [PubMed] [Google Scholar]
  9. Graziani G., Cantaluppi A., Casati S., Citterio A., Scalamogna A., Aroldi A., Silenzio R., Brancaccio D., Ponticelli C. Dopamine and frusemide in oliguric acute renal failure. Nephron. 1984;37(1):39–42. doi: 10.1159/000183205. [DOI] [PubMed] [Google Scholar]
  10. Parker S., Carlon G. C., Isaacs M., Howland W. S., Kahn R. C. Dopamine administration in oliguria and oliguric renal failure. Crit Care Med. 1981 Sep;9(9):630–632. doi: 10.1097/00003246-198109000-00002. [DOI] [PubMed] [Google Scholar]
  11. Riviere J. E., Coppoc G. L. Pharmacokinetics of gentamicin in the juvenile dog. Am J Vet Res. 1981 Sep;42(9):1621–1623. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES