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. 1986 Jan;29(1):171–174. doi: 10.1128/aac.29.1.171

Acyclic guanosine analogs as substrates for varicella-zoster virus thymidine kinase.

A R Karlström, C F Källander, G Abele, A Larsson
PMCID: PMC180389  PMID: 3015002

Abstract

This study was performed to obtain information on the enzymatic background to the antiviral activity of acyclic guanosine analogs. Five acyclic guanosine analogs, the (R)- and (S)-enantiomers of 9-(3,4-dihydroxybutyl)guanine, 9-(4-hydroxybutyl)guanine, 9-[(2-hydroxyethoxy)methyl]guanine, and 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine, were compared in enzyme kinetic experiments using purified varicella-zoster virus and human placenta mitochondrial thymidine kinase (TK). All analogs showed competitive patterns of inhibition in the phosphorylation of thymidine by varicella-zoster virus TK, but only low affinities and phosphorylation rates were observed. No affinity for the mitochondrial TK was observed for any of the analogs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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