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. 1986 Mar;29(3):383–385. doi: 10.1128/aac.29.3.383

Single-dose cephalexin therapy for acute bacterial urinary tract infections and acute urethral syndrome with bladder bacteriuria.

J Cardenas, E L Quinn, G Rooker, J Bavinger, D Pohlod
PMCID: PMC180398  PMID: 3717940

Abstract

The efficacy of single-dose therapy with 3 g of cephalexin was evaluated in 129 women with symptoms of acute uncomplicated lower urinary tract infections. Of 91 patients with significant bacteriuria, 61 (67%) were cured of their original infection; this was similar to the 54 to 79% cure rates reported in unselected populations of women of a wide age range treated for acute uncomplicated urinary tract infections with a single dose of amoxicillin or trimethoprim-sulfamethoxazole (J. Rosenstock, L. P. Smith, M. Gurney, K. Lee, W. G. Weinberg, J. N. Longfield, W. B. Tauber, and W. W. Karney, Antimicrob. Agents Chemother. 27:652-654, 1985; N. E. Tolkoff-Rubin, M. E. Wilson, P. Zuromskis, I. Jacoby, A. R. Martin, and R. H. Rubin, Antimicrob. Agents Chemother. 25:626-629, 1984). The cure rates of (87%) for our younger patients, those less than 25 years of age, was better than that (46%) for our patients over 40 years of age (P less than 0.001). Patients with infections that were negative in an antibody-coated bacteria test were cured at a significantly higher rate than those with infections that were positive in an antibody-coated bacteria test (71 versus 19%; P = 0.003). Those patients with infections caused by cephalexin-susceptible organisms were cured at a rate similar to that for patients with infections caused by cephalexin-resistant organisms (68 versus 50%; P = 0.62). The cure rate for suburban patients was 90%, versus 45% for inner-city patients (P = 0.008). Of the 28 women with acute urethral syndrome due to low-level bacteriuria, 27 were cured.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brumfitt W., Faiers M. C., Franklin I. N. The treatment of urinary infection by means of a single dose of cephaloridine. Postgrad Med J. 1970 Oct;(Suppl):65–69. [PubMed] [Google Scholar]
  2. Buckwold F. J., Ludwig P., Harding G. K., Thompson L., Slutchuk M., Shaw J., Ronald A. R. Therapy for acute cystitis in adult women. Randomized comparison of single-dose sulfisoxazole vs trimethoprim-sulfamethoxazole. JAMA. 1982 Apr 2;247(13):1839–1842. [PubMed] [Google Scholar]
  3. Greenberg R. N., Sanders C. V., Lewis A. C., Marier R. L. Single-dose cefaclor therapy of urinary tract infection. Evaluation of antibody-coated bacteria test and C-reactive protein assay as predictors of cure. Am J Med. 1981 Nov;71(5):841–845. doi: 10.1016/0002-9343(81)90377-6. [DOI] [PubMed] [Google Scholar]
  4. Griffith R. S., Black H. R. Blood, urine and tissue concentrations of the cephalosporin antibiotics in normal subjects. Postgrad Med J. 1971 Feb;47(Suppl):32–40. [PubMed] [Google Scholar]
  5. McAllister C. K., Mitchell C., Davis C. E., Jr, Buesing M. A., Dudley M., Carpenter J. L. Single-dose amoxicillin therapy of urinary tract infection among an unselected population of women. Mil Med. 1984 Apr;149(4):210–212. [PubMed] [Google Scholar]
  6. Pfau A., Sacks T. G., Shapiro A., Shapiro M. A randomized comparison of 1-day versus 10-day antibacterial treatment of documented lower urinary tract infection. J Urol. 1984 Nov;132(5):931–933. doi: 10.1016/s0022-5347(17)49952-6. [DOI] [PubMed] [Google Scholar]
  7. Rosenstock J., Smith L. P., Gurney M., Lee K., Weinberg W. G., Longfield J. N., Tauber W. B., Karney W. W. Comparison of single-dose tetracycline hydrochloride to conventional therapy of urinary tract infections. Antimicrob Agents Chemother. 1985 Apr;27(4):652–654. doi: 10.1128/aac.27.4.652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Rubin R. H., Fang L. S., Jones S. R., Munford R. S., Slepack J. M., Varga P. A., Onheiber L., Hall C. L., Tolkoff-Rubin N. E. Single-dose amoxicillin therapy for urinary tract infection. Multicenter trial using antibody-coated bacteria localization technique. JAMA. 1980 Aug 8;244(6):561–564. [PubMed] [Google Scholar]
  9. Savard-Fenton M., Fenton B. W., Reller L. B., Lauer B. A., Byyny R. L. Single-dose amoxicillin therapy with follow-up urine culture. Effective initial management for acute uncomplicated urinary tract infections. Am J Med. 1982 Dec;73(6):808–813. doi: 10.1016/0002-9343(82)90762-8. [DOI] [PubMed] [Google Scholar]
  10. Schultz H. J., McCaffrey L. A., Keys T. F., Nobrega F. T. Acute cystitis: a prospective study of laboratory tests and duration of therapy. Mayo Clin Proc. 1984 Jun;59(6):391–397. doi: 10.1016/s0025-6196(12)61461-x. [DOI] [PubMed] [Google Scholar]
  11. Sheehan G., Harding G. K., Ronald A. R. Advances in the treatment of urinary tract infection. Am J Med. 1984 May 15;76(5A):141–147. doi: 10.1016/0002-9343(84)90256-0. [DOI] [PubMed] [Google Scholar]
  12. Souney P., Polk B. F. Single-dose antimicrobial therapy for urinary tract infections in women. Rev Infect Dis. 1982 Jan-Feb;4(1):29–34. doi: 10.1093/clinids/4.1.29. [DOI] [PubMed] [Google Scholar]
  13. Stamm W. E., Wagner K. F., Amsel R., Alexander E. R., Turck M., Counts G. W., Holmes K. K. Causes of the acute urethral syndrome in women. N Engl J Med. 1980 Aug 21;303(8):409–415. doi: 10.1056/NEJM198008213030801. [DOI] [PubMed] [Google Scholar]
  14. Thomas V., Shelokov A., Forland M. Antibody-coated bacteria in the urine and the site of urinary-tract infection. N Engl J Med. 1974 Mar 14;290(11):588–590. doi: 10.1056/NEJM197403142901102. [DOI] [PubMed] [Google Scholar]
  15. Tolkoff-Rubin N. E., Wilson M. E., Zuromskis P., Jacoby I., Martin A. R., Rubin R. H. Single-dose amoxicillin therapy of acute uncomplicated urinary tract infections in women. Antimicrob Agents Chemother. 1984 May;25(5):626–629. doi: 10.1128/aac.25.5.626. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Weinstein A. J. Cephalexin in the therapy of infections of the urinary tract. Postgrad Med J. 1983;59 (Suppl 5):40–42. [PubMed] [Google Scholar]

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