Abstract
The susceptibilities of varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) to 17 nucleoside analogs were compared by a plaque reduction assay with human embryonic lung fibroblast cells. The susceptibility of VZV to certain nucleoside analogs was different from that of HSV-1. Against VZV the 5-halogenovinyl-arabinosyluracils were the most potent of the compounds tested.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cheng Y. C., Dutschman G., Fox J. J., Watanabe K. A., Machida H. Differential activity of potential antiviral nucleoside analogs on herpes simplex virus-induced and human cellular thymidine kinases. Antimicrob Agents Chemother. 1981 Sep;20(3):420–423. doi: 10.1128/aac.20.3.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cheng Y. C., Tsou T. Y., Hackstadt T., Mallavia L. P. Induction of thymidine kinase and DNase in varicella-zoster virus-infected cells and kinetic properties of the virus-induced thymidine kinase. J Virol. 1979 Jul;31(1):172–177. doi: 10.1128/jvi.31.1.172-177.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- De Clercq E. Comparative efficacy of antiherpes drugs in different cell lines. Antimicrob Agents Chemother. 1982 Apr;21(4):661–663. doi: 10.1128/aac.21.4.661. [DOI] [PMC free article] [PubMed] [Google Scholar]
- De Clercq E., Descamps J., Ogata M., Shigeta S. In vitro susceptibility of varicella-zoster virus to E-5-(2-bromovinyl)-2'-deoxyuridine and related compounds. Antimicrob Agents Chemother. 1982 Jan;21(1):33–38. doi: 10.1128/aac.21.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
- De Clercq E., Descamps J., Verhelst G., Walker R. T., Jones A. S., Torrence P. F., Shugar D. Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus. J Infect Dis. 1980 May;141(5):563–574. doi: 10.1093/infdis/141.5.563. [DOI] [PubMed] [Google Scholar]
- Machida H., Kuninaka A., Yoshino H. Inhibitory effects of antiherpesviral thymidine analogs against varicella-zoster virus. Antimicrob Agents Chemother. 1982 Feb;21(2):358–361. doi: 10.1128/aac.21.2.358. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Machida H., Sakata S. In vitro and in vivo antiviral activity of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) and related compounds. Antiviral Res. 1984 Jun;4(3):135–141. doi: 10.1016/0166-3542(84)90013-5. [DOI] [PubMed] [Google Scholar]
- Machida H., Sakata S., Kuninaka A., Yoshino H. Antiherpesviral and anticellular effects of 1-beta-D-arabinofuranosyl-E-5-(2-halogenovinyl) uracils. Antimicrob Agents Chemother. 1981 Jul;20(1):47–52. doi: 10.1128/aac.20.1.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ogino T., Otsuka T., Takahashi M. Induction of deoxypyrimidine kinase activity in human embryonic lung cells infected with varicella-zoster virus. J Virol. 1977 Mar;21(3):1232–1235. doi: 10.1128/jvi.21.3.1232-1235.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reefschläger J., Herrmann G., Bärwolff D., Schwarz B., Cech D., Langen P. Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines. Antiviral Res. 1983 Sep;3(3):175–187. doi: 10.1016/0166-3542(83)90024-4. [DOI] [PubMed] [Google Scholar]
- Sakata S., Shibuya S., Machida H., Yoshino H., Hirota K., Senda S., Ikeda K., Mizuno Y. Synthesis and antiherpesviral activity of 5-C-substituted uracil nucleosides. Nucleic Acids Symp Ser. 1980;(8):s39–s42. [PubMed] [Google Scholar]
- Shigeta S., Yokota T., Iwabuchi T., Baba M., Konno K., Ogata M., De Clercq E. Comparative efficacy of antiherpes drugs against various strains of varicella-zoster virus. J Infect Dis. 1983 Mar;147(3):576–584. doi: 10.1093/infdis/147.3.576. [DOI] [PubMed] [Google Scholar]