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. 1986 Apr;29(4):565–569. doi: 10.1128/aac.29.4.565

Combined action of chloramphenicol and ampicillin on chloramphenicol-resistant Haemophilus influenzae.

A M Mackenzie, F T Chan
PMCID: PMC180442  PMID: 3486629

Abstract

The interaction of ampicillin and chloramphenicol on three ampicillin-susceptible, chloramphenicol-resistant strains of Haemophilus influenzae was studied by checkerboard testing with subcultures, time-kill experiments, and a disk method. In all three strains there was inhibition of the bactericidal action of ampicillin by chloramphenicol at concentrations close to the MIC (10 micrograms/ml). This chloramphenicol concentration was close to that which might be achieved in cerebrospinal fluid during treatment for meningitis and was in the bactericidal range for chloramphenicol-susceptible organisms. It is suggested however that in the initial treatment of meningitis caused by ampicillin-susceptible, chloramphenicol-resistant strains, inhibition of the action of ampicillin by chloramphenicol may represent a clinical risk.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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