Abstract
The antifungal activity of UK 49,858, a difluorophenyl bis-triazole derivative, was evaluated in vitro against seven strains of Histoplasma capsulatum and in vivo in AKR and C57BL/6 murine models of histoplasmosis. UK 49,858 had a lower toxicity for AKR and C57BL/6 mice than amphotericin B did. The therapeutic index of UK 49,858 was 4.3 for AKR mice and 7.1 for C57BL/6; with amphotericin B it was 2 for both mouse strains. Given orally, UK 49,858 compared favorably with amphotericin B given intraperitoneally in either AKR or C57BL/6 mice infected with H. capsulatum.
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Selected References
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- Burt W. R., Underwood A. L., Appleton G. L. Hydroxamic acid from Histoplasma capsulatum that displays growth factor activity. Appl Environ Microbiol. 1981 Sep;42(3):560–563. doi: 10.1128/aem.42.3.560-563.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heeres J., Hendrickx R., Van Cutsem J. Antimycotic azoles. 6. Synthesis and antifungal properties of terconazole, a novel triazole ketal. J Med Chem. 1983 Apr;26(4):611–613. doi: 10.1021/jm00358a032. [DOI] [PubMed] [Google Scholar]
- Kobayashi G. S., Little J. R., Medoff G. In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester. Antimicrob Agents Chemother. 1985 Mar;27(3):302–305. doi: 10.1128/aac.27.3.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Richardson K., Brammer K. W., Marriott M. S., Troke P. F. Activity of UK-49,858, a bis-triazole derivative, against experimental infections with Candida albicans and Trichophyton mentagrophytes. Antimicrob Agents Chemother. 1985 May;27(5):832–835. doi: 10.1128/aac.27.5.832. [DOI] [PMC free article] [PubMed] [Google Scholar]