Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1986 Apr;29(4):713–715. doi: 10.1128/aac.29.4.713

In vitro activity of clavulanic acid, amoxicillin, and ticarcillin against Chlamydia trachomatis.

W R Bowie
PMCID: PMC180474  PMID: 3707116

Abstract

In vitro, growth of Chlamydia trachomatis was not entirely eliminated by 960 micrograms of ticarcillin per ml, 64 micrograms of amoxicillin per ml, 32 micrograms of clavulanic acid per ml, a combination of ticarcillin (480 micrograms/ml) and clavulanic acid (32 micrograms/ml), and a combination of amoxicillin (32 micrograms/ml) and clavulanic acid (8 micrograms/ml). However, a greater than or equal to 99% decrease in the number of inclusions was obtained at concentrations readily attainable in serum.

Full text

PDF
713

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Becker Y., Asher Y. Synthesis of trachoma agent proteins in emetine-treated cells. J Bacteriol. 1972 Mar;109(3):966–970. doi: 10.1128/jb.109.3.966-970.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bowie W. R., Alexander E. R., Holmes K. K. Eradication of Chlamydia trachomatis from the urethras of men with nongonococcal urethritis by treatment with amoxicillin. Sex Transm Dis. 1981 Apr-Jun;8(2):79–81. doi: 10.1097/00007435-198104000-00010. [DOI] [PubMed] [Google Scholar]
  3. Bowie W. R. Lack of in vitro activity of cefoxitin, cefamandole, cefuroxime, and piperacillin against Chlamydia trachomatis. Antimicrob Agents Chemother. 1982 Feb;21(2):339–340. doi: 10.1128/aac.21.2.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bowie W. R., Lee C. K., Alexander E. R. Prediction of efficacy of antimicrobial agents in treatment of infections due to Chlamydia trachomatis. J Infect Dis. 1978 Nov;138(5):655–659. doi: 10.1093/infdis/138.5.655. [DOI] [PubMed] [Google Scholar]
  5. Bowie W. R., Manzon L. M., Borrie-Hume C. J., Fawcett A., Jones H. D. Efficacy of treatment regimens for lower urogenital Chlamydia trachomatis infection in women. Am J Obstet Gynecol. 1982 Jan 15;142(2):125–129. doi: 10.1016/s0002-9378(16)32325-0. [DOI] [PubMed] [Google Scholar]
  6. Brogden R. N., Carmine A., Heel R. C., Morley P. A., Speight T. M., Avery G. S. Amoxycillin/clavulanic acid: a review of its antibacterial activity, pharmacokinetics and therapeutic use. Drugs. 1981 Nov;22(5):337–362. doi: 10.2165/00003495-198122050-00001. [DOI] [PubMed] [Google Scholar]
  7. Hammerschlag M. R., Gleyzer A. In vitro activity of a group of broad-spectrum cephalosporins and other beta-lactam antibiotics against Chlamydia trachomatis. Antimicrob Agents Chemother. 1983 Mar;23(3):493–494. doi: 10.1128/aac.23.3.493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Holmes K. K., Eschenbach D. A., Knapp J. S. Salpingitis: overview of etiology and epidemiology. Am J Obstet Gynecol. 1980 Dec 1;138(7 Pt 2):893–900. doi: 10.1016/0002-9378(80)91078-9. [DOI] [PubMed] [Google Scholar]
  9. Johannisson G., Sernryd A., Lycke E. Susceptibility of Chlamydia trachomatis to antibiotics in vitro and in vivo. Sex Transm Dis. 1979 Apr-Jun;6(2):50–57. doi: 10.1097/00007435-197904000-00002. [DOI] [PubMed] [Google Scholar]
  10. Kramer M. J., Gordon F. B. Ultrastructural analysis of the effects of penicillin and chlortetracycline on the development of a genital tract Chlamydia. Infect Immun. 1971 Feb;3(2):333–341. doi: 10.1128/iai.3.2.333-341.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kuo C. C., Wang S. P., Grayston J. T. Antimicrobial activity of several antibiotics and a sulfonamide against Chlamydia trachomatis organisms in cell culture. Antimicrob Agents Chemother. 1977 Jul;12(1):80–83. doi: 10.1128/aac.12.1.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lee C. K., Bowie W. R., Alexander E. R. In vitro assays of the efficacy of antimicrobial agents in controlling Chlamydia trachomatis propagation. Antimicrob Agents Chemother. 1978 Mar;13(3):441–445. doi: 10.1128/aac.13.3.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ridgway G. L., Owen J. M., Oriel J. D. The antimicrobial susceptibility of Chlamydia trachomatis in cell culture. Br J Vener Dis. 1978 Apr;54(2):103–106. doi: 10.1136/sti.54.2.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Stamm W. E., Wagner K. F., Amsel R., Alexander E. R., Turck M., Counts G. W., Holmes K. K. Causes of the acute urethral syndrome in women. N Engl J Med. 1980 Aug 21;303(8):409–415. doi: 10.1056/NEJM198008213030801. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES