Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1986 Jun;29(6):1040–1046. doi: 10.1128/aac.29.6.1040

Role of a novel antidiarrheal agent, BW942C, alone or in combination with trimethoprim-sulfamethoxazole in the treatment of traveler's diarrhea.

C D Ericsson, P C Johnson, H L DuPont, D R Morgan
PMCID: PMC180497  PMID: 3524436

Abstract

The efficacy of BW942C, a novel enkephalinlike pentapeptide antidiarrheal agent, was compared with the efficacy of trimethoprim-sulfamethoxazole (TMP-SMX) and the combination of the two agents in a placebo-controlled trial of the 72-h treatment of acute diarrhea. Subjects with diarrhea but without bloody stools or fever greater than 102 degrees F (38.9 degrees C) were enrolled. Administered to 134 U.S. adults with diarrhea that developed shortly after their arrival in Guadalajara, Mexico, BW942C was more efficacious than TMP-SMX in relieving diarrhea and cramps in the first 12 h of therapy, especially among subjects with diarrhea caused by enterotoxigenic E. coli. In the BW942C treatment group, 25% of subjects eventually took additional therapy because their diarrhea did not respond to BW942C alone. Neurological side effects such as dizziness and light-headedness occurred more frequently among BW942C-treated subjects. Therapy for 3 days with TMP-SMX provided lasting relief comparable with previously reported 5-day therapy. Use of the combination of both agents provided the benefits of prompt relief afforded by BW942C and lasting relief afforded by TMP-SMX. BW942C might prove to be an agent suitable for the treatment of acute diarrhea, with TMP-SMX reserved for treatment of those who do not respond adequately. The empiric use of the combination of BW942C and TMP-SMX appears appropriate for the treatment of severe nondysenteric disease.

Full text

PDF
1040

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DuPont H. L., Evans D. G., Rios N., Cabada F. J., Evans D. J., Jr, DuPont M. W. Prevention of travelers' diarrhea with trimethoprim-sulfamethoxazole. Rev Infect Dis. 1982 Mar-Apr;4(2):533–539. doi: 10.1093/clinids/4.2.533. [DOI] [PubMed] [Google Scholar]
  2. DuPont H. L., Galindo E., Evans D. G., Cabada F. J., Sullivan P., Evans D. J., Jr Prevention of travelers' diarrhea with trimethoprim-sulfamethoxazole and trimethoprim alone. Gastroenterology. 1983 Jan;84(1):75–80. [PubMed] [Google Scholar]
  3. DuPont H. L., Hornick R. B. Adverse effect of lomotil therapy in shigellosis. JAMA. 1973 Dec 24;226(13):1525–1528. [PubMed] [Google Scholar]
  4. DuPont H. L., Reves R. R., Galindo E., Sullivan P. S., Wood L. V., Mendiola J. G. Treatment of travelers' diarrhea with trimethoprim/sulfamethoxazole and with trimethoprim alone. N Engl J Med. 1982 Sep 30;307(14):841–844. doi: 10.1056/NEJM198209303071401. [DOI] [PubMed] [Google Scholar]
  5. Dupont H. L., Haynes G. A., Pickering L. K., Tjoa W., Sullivan P., Olarte J. Diarrhea of travelers to Mexico. Relative susceptibility of United States and Latin American students attending a Mexican University. Am J Epidemiol. 1977 Jan;105(1):37–41. doi: 10.1093/oxfordjournals.aje.a112353. [DOI] [PubMed] [Google Scholar]
  6. Ericsson C. D., DuPont H. L., Galindo E., Mathewson J. J., Morgan D. R., Wood L. V., Mendiola J. Efficacy of bicozamycin in preventing traveler's diarrhea. Gastroenterology. 1985 Feb;88(2):473–477. doi: 10.1016/0016-5085(85)90509-8. [DOI] [PubMed] [Google Scholar]
  7. Ericsson C. D., DuPont H. L., Sullivan P., Galindo E., Evans D. G., Evans D. J., Jr Bicozamycin, a poorly absorbable antibiotic, effectively treats travelers' diarrhea. Ann Intern Med. 1983 Jan;98(1):20–25. doi: 10.7326/0003-4819-98-1-20. [DOI] [PubMed] [Google Scholar]
  8. Morgan D. R., Sellin J., Gutierrez L., DuPont H. L., Wood L. V. Evaluation of BW942C, a novel antidiarrheal agent, against enterotoxins of Escherichia coli and Vibrio cholerae. Infect Immun. 1985 Jun;48(3):754–758. doi: 10.1128/iai.48.3.754-758.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pickering L. K., DuPont H. L., Olarte J. Single-dose tetracycline therapy for shigellosis in adults. JAMA. 1978 Feb 27;239(9):853–854. [PubMed] [Google Scholar]
  10. Thorén A., Wolde-Mariam T., Stintzing G., Wadström T., Habte D. Antibiotics in the treatment of gastroenteritis caused by enteropathogenic Escherichia coli. J Infect Dis. 1980 Jan;141(1):27–31. doi: 10.1093/infdis/141.1.27. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES