Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1986 Jun;29(6):1092–1094. doi: 10.1128/aac.29.6.1092

In vitro and in vivo efficacy of the combination trimethoprim-sulfamethoxazole against clinical isolates of methicillin-resistant Staphylococcus aureus.

L P Elwell, H R Wilson, V B Knick, B R Keith
PMCID: PMC180506  PMID: 3488022

Abstract

The in vitro susceptibilities of 16 independent, geographically distinct clinical isolates of methicillin-resistant Staphylococcus aureus to trimethoprim (TMP) in combination with sulfamethoxazole (SMX) were evaluated. Although methicillin-resistant S. aureus strains appear to be universally resistant to SMX, the combination TMP-SMX was found to be synergistic in vitro (in combination, the MICs of both drugs decreased 6- to 25-fold) as well as in vivo (5- to 6-fold reduction in TMP at 50% effective doses).

Full text

PDF
1092

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bengtsson E., Svanbom M., Tunevall G. Trimethoprim-sulphamethoxazole treatment in staphylococcal endocarditis and gram-negative septicemia. Scand J Infect Dis. 1974;6(2):177–182. doi: 10.3109/inf.1974.6.issue-2.13. [DOI] [PubMed] [Google Scholar]
  2. Ellison R. T., 3rd, Judson F. N., Peterson L. C., Cohn D. L., Ehret J. M. Oral rifampin and trimethoprim/sulfamethoxazole therapy in asymptomatic carriers of methicillin-resistant Staphylococcus aureus infections. West J Med. 1984 May;140(5):735–740. [PMC free article] [PubMed] [Google Scholar]
  3. Farid Z., Girgis N. I., Yassin W. Letter: Trimethoprim-sulfamethoxazole and bacterial meningitis. Ann Intern Med. 1976 Jan;84(1):50–51. doi: 10.7326/0003-4819-84-1-50. [DOI] [PubMed] [Google Scholar]
  4. Foldes M., Munro R., Sorrell T. C., Shanker S., Toohey M. In-vitro effects of vancomycin, rifampicin, and fusidic acid, alone and in combination, against methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother. 1983 Jan;11(1):21–26. doi: 10.1093/jac/11.1.21. [DOI] [PubMed] [Google Scholar]
  5. Gopal V., Bisno A. L., Silverblatt F. J. Failure of vancomycin treatment in Staphylococcus aureus endocarditis. In vivo and in vitro observations. JAMA. 1976 Oct 4;236(14):1604–1606. [PubMed] [Google Scholar]
  6. Moellering R. C., Jr Antimicrobial synergism--an elusive concept. J Infect Dis. 1979 Oct;140(4):639–641. doi: 10.1093/infdis/140.4.639. [DOI] [PubMed] [Google Scholar]
  7. Sabel K. G., Brandberg A. Treatment of meningitis and septicemia in infancy with a sulphamethoxazole/trimethorpim combination. Acta Paediatr Scand. 1975 Jan;64(1):25–32. doi: 10.1111/j.1651-2227.1975.tb04376.x. [DOI] [PubMed] [Google Scholar]
  8. Schaefler S., Jones D., Perry W., Ruvinskaya L., Baradet T., Mayr E., Wilson M. E. Emergence of gentamicin- and methicillin-resistant Staphylococcus aureus strains in New York City hospitals. J Clin Microbiol. 1981 Apr;13(4):754–759. doi: 10.1128/jcm.13.4.754-759.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Tamer M. A., Bray J. D. Trimethoprim-sulfamethoxazole treatment of multiantibiotic-resistant staphylococcal endocarditis and meningitis. Clin Pediatr (Phila) 1982 Feb;21(2):125–126. doi: 10.1177/000992288202100211. [DOI] [PubMed] [Google Scholar]
  10. Wenzel R. P. The emergence of methicillin-resistant Staphylococcus aureus. Ann Intern Med. 1982 Sep;97(3):440–442. doi: 10.7326/0003-4819-97-3-440. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES