Abstract
Oral cefuroxime axetil (1 g) plus probenecid cured 29 of 30 urethral and 6 of 6 rectal gonococcal infections in men; alone the drug cured 22 of 23 urethral and 4 of 6 rectal infections. No toxicity was observed. Cefuroxime axetil alone is effective for urethral gonorrhea in males; rectal gonorrhea probably requires additional probenecid.
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Selected References
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- Foord R. D. Cefuroxime: human pharmacokinetics.. Antimicrob Agents Chemother. 1976 May;9(5):741–747. doi: 10.1128/aac.9.5.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gold B., Rodriguez W. J. Cefuroxime: mechanisms of action, antimicrobial activity, pharmacokinetics, clinical applications, adverse reactions and therapeutic indications. Pharmacotherapy. 1983 Mar-Apr;3(2 Pt 1):82–100. [PubMed] [Google Scholar]
- Hall W. H., Opfer B. J. Influence of inoculum size on comparative susceptibilities of penicillinase-positive and -negative Neisseria gonorrhoeae to 31 antimicrobial agents. Antimicrob Agents Chemother. 1984 Aug;26(2):192–195. doi: 10.1128/aac.26.2.192. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harding S. M., Williams P. E., Ayrton J. Pharmacology of Cefuroxime as the 1-acetoxyethyl ester in volunteers. Antimicrob Agents Chemother. 1984 Jan;25(1):78–82. doi: 10.1128/aac.25.1.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jones K. H., Langley P. F., Lees L. J. Bioavailability and metabolism of talampicillin. Chemotherapy. 1978;24(4):217–226. doi: 10.1159/000237784. [DOI] [PubMed] [Google Scholar]
- Khan M. Y., Gruninger R. P., Nelson S. M., Obaid S. R. Comparative in vitro activity of cefodizime, ceftazidime, aztreonam, and other selected antimicrobial agents against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1983 Mar;23(3):477–478. doi: 10.1128/aac.23.3.477. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ng W. S., Chau P. Y., Ling J., Echeverria P., Rockhill R., Arnold K. Penicillinase-producing Neisseria gonorrhoeae isolates from different localities in south east Asia. Susceptibility to 15 antibiotics. Br J Vener Dis. 1983 Aug;59(4):232–236. doi: 10.1136/sti.59.4.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Reichman R. C., Nolte F. S., Wolinsky S. M., Greisberger C. A., Trupei M. A., Nitzkin J. Single-dose cefuroxime axetil in the treatment of uncomplicated gonorrhea: a controlled trial. Sex Transm Dis. 1985 Oct-Dec;12(4):184–187. doi: 10.1097/00007435-198510000-00003. [DOI] [PubMed] [Google Scholar]
- Ruckdeschel G., Neubert U., Korting H. C. Distribution of auxotypes and correlation to antibiotic susceptibility of 169 recent clinical Neisseria gonorrhoeae isolates from Munich. Arch Dermatol Res. 1983;275(6):388–392. doi: 10.1007/BF00417339. [DOI] [PubMed] [Google Scholar]
- Sommers D. K., van Wyk M., Moncrieff J., Schoeman H. S. Influence of food and reduced gastric acidity on the bioavailability of bacampicillin and cefuroxime axetil. Br J Clin Pharmacol. 1984 Oct;18(4):535–539. doi: 10.1111/j.1365-2125.1984.tb02501.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stolz E., Ong L., van Joost T., Michel M. F. Treatment of non-complicated urogenital, rectal and oropharyngeal gonorrhoea with intramuscular cefotaxime 1.0 g or cefuroxime 1.5 g. J Antimicrob Chemother. 1984 Sep;14 (Suppl B):295–299. doi: 10.1093/jac/14.suppl_b.295. [DOI] [PubMed] [Google Scholar]
- Tupasi T. E., Crisologo L. B., Torres C. A., Calubiran O. V., de Jesus I. Cefuroxime, thiamphenicol, spectinomycin, and penicillin G in uncomplicated infections due to penicillinase-producing strains of Neisseria gonorrhoeae. Br J Vener Dis. 1983 Jun;59(3):172–175. doi: 10.1136/sti.59.3.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williams P. E., Harding S. M. The absolute bioavailability of oral cefuroxime axetil in male and female volunteers after fasting and after food. J Antimicrob Chemother. 1984 Feb;13(2):191–196. doi: 10.1093/jac/13.2.191. [DOI] [PubMed] [Google Scholar]