Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1986 Aug;30(2):340–341. doi: 10.1128/aac.30.2.340

In vitro cytotoxicity and antibiotic activity of polymyxin B nonapeptide.

A K Duwe, C A Rupar, G B Horsman, S I Vas
PMCID: PMC180550  PMID: 3021053

Abstract

Polymyxin B nonapeptide, prepared by enzymic removal of the fatty acyl diaminobutyric acid side chain from polymyxin B, was about 100-fold less toxic to K562 cells than polymyxin B. MICs of polymyxin B nonapeptide against a test panel of bacteria were 2- to 64-fold lower than those of polymyxin B.

Full text

PDF
340

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Rosenthal K. S., Storm D. R. Disruption of the Escherichia coli outer membrane permeability barrier by immobilized polymyxin B. J Antibiot (Tokyo) 1977 Dec;30(12):1087–1092. doi: 10.7164/antibiotics.30.1087. [DOI] [PubMed] [Google Scholar]
  2. Storm D. R., Rosenthal K. S., Swanson P. E. Polymyxin and related peptide antibiotics. Annu Rev Biochem. 1977;46:723–763. doi: 10.1146/annurev.bi.46.070177.003451. [DOI] [PubMed] [Google Scholar]
  3. Vaara M., Vaara T. Polycations as outer membrane-disorganizing agents. Antimicrob Agents Chemother. 1983 Jul;24(1):114–122. doi: 10.1128/aac.24.1.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Vaara M., Viljanen P. Binding of polymyxin B nonapeptide to gram-negative bacteria. Antimicrob Agents Chemother. 1985 Apr;27(4):548–554. doi: 10.1128/aac.27.4.548. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Vaara M., Viljanen P., Vaara T., Mäkelä P. H. An outer membrane-disorganizing peptide PMBN sensitizes E. coli strains to serum bactericidal action. J Immunol. 1984 May;132(5):2582–2589. [PubMed] [Google Scholar]
  6. Viljanen P., Vaara M. Susceptibility of gram-negative bacteria to polymyxin B nonapeptide. Antimicrob Agents Chemother. 1984 Jun;25(6):701–705. doi: 10.1128/aac.25.6.701. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES