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. 1986 Dec;30(6):835–839. doi: 10.1128/aac.30.6.835

Penicillins, cephalosporins, and tetracyclines in treatment of hamsters with fatal leptospirosis.

A D Alexander, P L Rule
PMCID: PMC180603  PMID: 3813511

Abstract

A predictable 6- to 7-day course of a fatal Leptospira interrogans serovar bataviae infection in experimentally infected mature 110- to 150-g hamsters was used to evaluate the therapeutic efficacy of conventionally used and newer antibiotics. Active drugs were ampicillin, bacampicillin, cyclacillin, piperacillin, mezlocillin, doxycycline, chlortetracycline, cefotaxime, and moxalactam. Cephalexin, cefadroxil, cefamandole, and cefoperazone showed little or no activity in preliminary studies. In delayed treatment studies, all nine active drugs prevented death of hamsters even when treatment was delayed until 1 to 2.5 days before expected time of death. Leptospires in kidneys of surviving animals could be demonstrated in one or more hamsters treated with doxycycline, chlortetracycline, cyclacillin, and piperacillin, but in none of the animals treated with ampicillin, bacampicillin, mezlocillin, cefotaxime, and moxalactam. The potential usefulness of newer penicillins and cephalosporins, as well as ampicillin, chlortetracycline, and doxycycline, for treatment of severe leptospirosis is reported.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander A. D., Evans L. B., Baker M. F., Baker H. J., Ellison D., Marriapan M. Pathogenic leptospiras isolated from Malaysian surface waters. Appl Microbiol. 1975 Jan;29(1):30–33. doi: 10.1128/am.29.1.30-33.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Feigin R. D., Anderson D. C. Human leptospirosis. CRC Crit Rev Clin Lab Sci. 1975 Mar;5(4):413–467. doi: 10.3109/10408367509107050. [DOI] [PubMed] [Google Scholar]
  3. Füzi M. Ujabb antibiotikumok in vitro bakteriosztatikus hatása pathogen leptospirákra. Orv Hetil. 1982 Dec 19;123(51):3131–3132. [PubMed] [Google Scholar]
  4. GSELL O. [Antibiotic therapy of leptospiroses]. Schweiz Med Wochenschr. 1959 Apr 18;89:422–425. [PubMed] [Google Scholar]
  5. HALL H. E., HIGHTOWER J. A., DIAZ RIVERA R., BYRNE R. J., SMADEL J. E., WOODWARD T. E. Evaluation of antibiotic therapy in human leptospirosis. Ann Intern Med. 1951 Nov;35(5):981–998. doi: 10.7326/0003-4819-35-5-981. [DOI] [PubMed] [Google Scholar]
  6. HEGGLIN R., KEISER G., SIEGENTHALER W. Klinische Erfahrungen mit Romicil (Oleandomycin), einem neuen Antibiotikum. Dtsch Med Wochenschr. 1956 Dec 21;81(51):2074–2080. [PubMed] [Google Scholar]
  7. Kanazawa Y. [A case of Leptospira hebdomadis infection treated with piperacillin (author's transl)]. Jpn J Antibiot. 1979 Sep;32(9):966–970. [PubMed] [Google Scholar]
  8. Münnich D., Lakatos M. Treatment of human leptospira infections with semicillin (ampicillin) or with amoxil (amoxycillin). Chemotherapy. 1976;22(6):372–380. doi: 10.1159/000221949. [DOI] [PubMed] [Google Scholar]
  9. Oie S., Hironaga K., Koshiro A., Konishi H., Yoshii Z. In vitro susceptibilities of five Leptospira strains to 16 antimicrobial agents. Antimicrob Agents Chemother. 1983 Dec;24(6):905–908. doi: 10.1128/aac.24.6.905. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Takafuji E. T., Kirkpatrick J. W., Miller R. N., Karwacki J. J., Kelley P. W., Gray M. R., McNeill K. M., Timboe H. L., Kane R. E., Sanchez J. L. An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. N Engl J Med. 1984 Feb 23;310(8):497–500. doi: 10.1056/NEJM198402233100805. [DOI] [PubMed] [Google Scholar]
  11. WOOD G. E., ALEXANDER A. D. Tylosin therapy in experimental leptospirosis. Antibiot Chemother (Northfield) 1961 Sep;11:592–595. [PubMed] [Google Scholar]

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