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. 1986 Dec;30(6):940–941. doi: 10.1128/aac.30.6.940

Activity of ciprofloxacin against multiply resistant strains of Pseudomonas aeruginosa, Staphylococcus epidermidis, and group JK corynebacteria.

F R Venezio, W Tatarowicz, C A DiVincenzo, J P O'Keefe
PMCID: PMC180624  PMID: 3101589

Abstract

The susceptibilities of multiply resistant clinical isolates of Pseudomonas aeurginosa to ciprofloxacin, norfloxacin, and several beta-lactam and aminoglycoside antibiotics were evaluated. Ciprofloxacin also was compared with methicillin and vancomycin against methicillin-resistant Staphylococcus epidermidis and group JK corynebacteria. Ciprofloxacin exhibited the lowest MICs and MBCs for 90% of the isolates among all of the antibiotics tested against P. aeruginosa. In addition, ciprofloxacin exhibited excellent bactericidal activity against the gram-positive organisms. Clinical trials are necessary to confirm the in vitro results and monitor for emergence of resistance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Archer G. L., Tenenbaum M. J. Antibiotic-resistant Staphylococcus epidermidis in patients undergoing cardiac surgery. Antimicrob Agents Chemother. 1980 Feb;17(2):269–272. doi: 10.1128/aac.17.2.269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barry A. L., Jones R. N., Thornsberry C., Ayers L. W., Gerlach E. H., Sommers H. M. Antibacterial activities of ciprofloxacin, norfloxacin, oxolinic acid, cinoxacin, and nalidixic acid. Antimicrob Agents Chemother. 1984 May;25(5):633–637. doi: 10.1128/aac.25.5.633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chin N. X., Neu H. C. Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria. Antimicrob Agents Chemother. 1984 Mar;25(3):319–326. doi: 10.1128/aac.25.3.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Davies G. S., Cohen J. In-vitro study of the activity of ciprofloxacin alone and in combination against strains of Pseudomonas aeruginosa with multiple antibiotic resistance. J Antimicrob Chemother. 1985 Dec;16(6):713–717. doi: 10.1093/jac/16.6.713. [DOI] [PubMed] [Google Scholar]
  5. Eliopoulos G. M., Gardella A., Moellering R. C., Jr In vitro activity of ciprofloxacin, a new carboxyquinoline antimicrobial agent. Antimicrob Agents Chemother. 1984 Mar;25(3):331–335. doi: 10.1128/aac.25.3.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fass R. J. In vitro activity of ciprofloxacin (Bay o 9867). Antimicrob Agents Chemother. 1983 Oct;24(4):568–574. doi: 10.1128/aac.24.4.568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Garrelts J. C., Peterie J. D. Vancomycin and the "red man's syndrome". N Engl J Med. 1985 Jan 24;312(4):245–245. [PubMed] [Google Scholar]
  8. Kloos W. E., Schleifer K. H. Simplified scheme for routine identification of human Staphylococcus species. J Clin Microbiol. 1975 Jan;1(1):82–88. doi: 10.1128/jcm.1.1.82-88.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lowy F. D., Hammer S. M. Staphylococcus epidermidis infections. Ann Intern Med. 1983 Dec;99(6):834–839. doi: 10.7326/0003-4819-99-6-834. [DOI] [PubMed] [Google Scholar]
  10. Machka K., Balg H. In vitro activity of ciprofloxacin against group JK corynebacteria. Eur J Clin Microbiol. 1984 Aug;3(4):375–375. doi: 10.1007/BF01977504. [DOI] [PubMed] [Google Scholar]
  11. Mandell W., Neu H. C. In vitro activity of CI-934, a new quinolone, compared with that of other quinolones and other antimicrobial agents. Antimicrob Agents Chemother. 1986 May;29(5):852–857. doi: 10.1128/aac.29.5.852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Simberkoff M. S., Rahal J. J., Jr Bactericidal activity of ciprofloxacin against amikacin- and cefotaxime-resistant gram-negative bacilli and methicillin-resistant staphylococci. Antimicrob Agents Chemother. 1986 Jun;29(6):1098–1100. doi: 10.1128/aac.29.6.1098. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Stamm W. E., Tompkins L. S., Wagner K. F., Counts G. W., Thomas E. D., Meyers J. D. Infection due to Corynebacterium species in marrow transplant patients. Ann Intern Med. 1979 Aug;91(2):167–173. doi: 10.7326/0003-4819-91-2-167. [DOI] [PubMed] [Google Scholar]
  14. Strikas R., Studlo J., Venezio F. R., O'Keefe J. P. Vancomycin-induced neutropenia. J Infect Dis. 1982 Oct;146(4):575–575. doi: 10.1093/infdis/146.4.575. [DOI] [PubMed] [Google Scholar]
  15. Thornsberry C., McDougal L. K. Successful use of broth microdilution in susceptibility tests for methicillin-resistant (heteroresistant) staphylococci. J Clin Microbiol. 1983 Nov;18(5):1084–1091. doi: 10.1128/jcm.18.5.1084-1091.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]

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